3-Hydroxymethylglutaric Acid Analysis Service
- Rapid Analysis Cycle and Cost-Effectiveness
- Stable, Reliable, and Highly Sensitive Results
- Comprehensive One-Stop Service for Extensive Testing Needs
- User-Friendly Operation with Wide Application Scope
- Supported by Extensive Bioanalytical Resources and Advanced Platforms
3-Hydroxymethylglutaric acid (3-HMGA, also known as 3-hydroxy-3-methylglutaric acid, β-hydroxy-β-methylglutaric acid, and Meglutol) is a crucial organic acid widely present in organisms, especially in mammalian metabolism. As an important intermediate in cholesterol and isoprenoid synthesis, 3-HMGA serves as a biomarker for various metabolic diseases and possesses antihyperlipidemic properties, reducing cholesterol and triglyceride levels by inhibiting HMG-CoA reductase, the rate-limiting enzyme in cholesterol biosynthesis. Abnormal levels of 3-HMGA are associated with diseases such as 3-hydroxy-3-methylglutaric aciduria, metabolic acidosis, and liver dysfunction. Accurate measurement of 3-HMGA is essential for disease diagnosis, health monitoring, and metabolic research.
Figure 1. Molecular Structure of 3-Hydroxymethylglutaric Acid
MtoZ Biolabs offers 3-Hydroxymethylglutaric Acid Analysis Service using ultra-performance liquid chromatography-mass spectrometry (UPLC-MS). This advanced method combines the separation capabilities of UPLC with the detection power of MS, ensuring high sensitivity and specificity in 3-HMGA detection.
Analysis Workflow
Service Advantages
Sample Submission Requirements
Make sure the sample volume is greater than 0.2 g or 0.2 mL. For detailed sample submission information, please contact our customer service.
Applications
1. Disease Diagnosis: Measure 3-HMGA levels to aid in diagnosing 3-hydroxy-3-methylglutaric aciduria, metabolic acidosis, and liver dysfunction.
2. Health Monitoring: Monitor changes in 3-HMGA levels to assess individual health status and disease risk.
3. Drug Research: Evaluate the impact of drugs on 3-HMGA metabolism, supporting new drug development and efficacy evaluation.
4. Metabolic Research: Study the role of 3-HMGA in the cholesterol and isoprenoid synthesis pathways to gain a deeper understanding of its biological functions and mechanisms.
5. Basic Biological Research: Investigate the role of 3-HMGA in metabolic networks, uncovering its regulatory mechanisms in organisms.
Deliverables
1. Experimental Procedures
2. Relevant Liquid Chromatography and Mass Spectrometry Parameters
3. Detailed Information on 3-Hydroxymethylglutaric Acid
4. Raw Data
5. Custom Analysis Report
Our 3-Hydroxymethylglutaric Acid Analysis Service provides high-quality data support, advancing your scientific research and applications. For any inquiries or requirements, please contact us.
How to order?
