Resources
Proteomics Databases
Metabolomics Databases
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• Fundamental Methods and Techniques of Infrared Spectroscopy Analysis
Infrared (IR) spectroscopy is a technique used to identify chemical bonds and functional groups in both organic and inorganic samples. Its principle is based on the absorption of infrared light at specific wavenumbers (typically expressed in cm⁻¹) by chemical bonds within molecules, resulting in vibrational transitions. The following outlines the essential steps and key considerations in infrared spectroscopy analysis: Understanding the Basics IR spectra are generally divided into two regions: the......
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• High-Content Screening Analysis
High-content screening analysis is a research platform focused on cell phenotyping that combines automated imaging, image recognition, and multi-parameter quantitative analysis. This technology is mainly employed to evaluate the functional effects of compounds, genes, or other interventions at the cellular level. One of its advantages is the generation of highly detailed data. Unlike traditional screening methods that offer only simple activity strength results, this technique provides high-dimensiona......
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10x Genomics TCR sequencing is a powerful method for exploring the diversity and detailed characteristics of T-cell receptors (TCRs), which are essential for T-cells to recognize and bind to antigens in the immune response. This technology allows researchers to obtain comprehensive TCR sequence information, including diversity, clonal expansion, and unique sequence traits. In basic immunology, it provides an invaluable tool for systematically studying T-cell development, differentiation, and response ......
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HTS drug screening is a technology-driven method that leverages automation, miniaturization, and parallel processing to assess the biological activity or mechanism of numerous candidate compounds efficiently. This approach significantly enhances the early stages of drug discovery, which are traditionally constrained by lengthy and costly processes. By simultaneously evaluating thousands to millions of samples, HTS drug screening has become a cornerstone of modern drug development. This technique is ......
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X-ray analysis of protein is a fundamental technique for determining the three-dimensional structures of proteins at atomic resolution. This method leverages X-ray diffraction principles to probe the atomic arrangement within protein crystals, enabling detailed insights into protein function and molecular mechanisms. The ability to obtain high-resolution structural data through biophysical characterization is essential for elucidating protein roles in cellular processes, guiding rational drug design, ......
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Ion channel drug discovery is an intricate process that integrates the study of membrane protein functions with high-throughput screening technologies. This approach aims to identify and develop compounds that specifically target ion channels to treat diseases associated with electrophysiological imbalances. Ion channels, which regulate the transmembrane transport of ions like sodium, potassium, calcium, and chloride, are crucial for cellular excitability, signal transduction, and osmotic regulation. ......
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• Proteomics in Drug Discovery
Proteomics in drug discovery refers to the comprehensive analysis of all proteins in a biological system to investigate their critical roles throughout the drug development process. As the primary functional molecules in living organisms, proteins are essential participants in nearly every cellular process, including gene regulation, signal transduction, and metabolism. Proteomics in drug discovery provides crucial biological insights that support various stages of pharmaceutical research, such as tar......
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Proteomic biomarkers are specific proteins or expression profiles indicative of diseases, pathological conditions, or physiological changes, identified through comprehensive protein analysis. These biomarkers, present in bodily fluids such as blood, urine, and saliva, are pivotal in linking protein levels, structures, or modifications to the onset, progression, treatment response, or prognosis of diseases. The clinical relevance of proteomic biomarkers is profound, especially for early disease diagnos......
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SILAC labeling is a widely utilized technique in proteomics that enables precise quantitative comparison of protein expression across different biological samples under defined cell culture conditions. This method incorporates stable isotope-labeled amino acids into cellular proteins during cultivation, allowing experimental and control groups to be distinguished based on isotopic differences. As these isotopically labeled amino acids do not interfere with protein structure or function, SILAC labeling......
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The synthesis of semaglutide refers to the integrated chemical and biological process of constructing this long-acting glucagon-like peptide-1 (GLP-1) receptor agonist. As a peptide-based therapeutic, semaglutide has demonstrated superior efficacy in the treatment of type 2 diabetes and obesity. Its primary mechanism of action involves mimicking the function of endogenous GLP-1 to regulate blood glucose and body weight by enhancing insulin secretion, delaying gastric emptying, and suppressing appetite......
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