Charge Heterogeneity Analysis Service

• • Monosaccharide Composition Analysis Service

  Monosaccharides are the simplest form of sugar molecules and cannot be further hydrolyzed into smaller units. Monosaccharide composition profiling refers to the identification and quantification of the monosaccharide components present in polysaccharides.

• • Sialic Acid Content Analysis Service

  Sialic acid, a carbohydrate prevalent throughout nature, primarily composes the glycoproteins and glycolipids of animal cell membranes and secretions, as well as substances in bacterial capsules. This sugar plays various pivotal biological roles and is notably valuable in the medical treatment of influenza, neurological disorders, inflammation, and cancer.

• • Ion Chromatography-Based Charge Heterogeneity Analysis Service

  In biopharmaceutical processes, particularly for protein and antibody drugs, charge heterogeneity analysis is crucial for ensuring quality control of bioproducts. Interactions between molecules with different charge can significantly impact the bioactivity, immunogenicity, half-life, and charge stability of drugs, ultimately affecting their efficacy, stability, and safety. Ion chromatography (IC) is a widely recognized technique for analyzing charge heterogeneity in biomolecules by leveraging the char......

• • cIEF Based Charge Heterogeneity Analysis Service

  Charge heterogeneity is a key attribute of biomolecules such as antibody, enzyme, and protein, affecting the molecule's stability, solubility, and biological activity. Changes of deamidation, oxidation, glycosylation, glycation, the N- or C-terminal, loss of three-dimensional structure, or reduction of disulfide bonds may lead to changes in charge heterogeneity. Since charge heterogeneity directly or indirectly affects the efficacy and safety of biomolecules, the analysis of charge heterogeneity occup......

• • Other Post-Translational Modification Analysis Service

  Post-translational modifications (PTMs) are the various chemical modifications that proteins undergo after translation is complete. Proteins are subject to a range of chemical modifications following synthesis, including phosphorylation, methylation, acetylation, ubiquitination, and among others. These modifications can significantly alter protein structure, function, and interaction, influencing cellular physiology and signal transduction.

• • Comprehensive Glycosylation Analysis Service

  Glycosylation is a very important type of protein post-translational modification (PTM). It is estimated that over half of eukaryotic proteins undergo glycosylation, with glycoproteins playing pivotal roles in many biological processes and have important cellular functions.

• • Protein Isoelectric Point Determination Service

  Proteins are ampholytes that contain both positively and negatively charged functional groups. Their net charge is predominantly determined by the pH of the surrounding environment. When the pH of the external environment makes the acidic and alkaline dissociations in the protein molecule balance, i.e., the positive and negative charges carried by the molecule are completely canceled out, this particular pH is known as the isoelectric point (pI) of that protein.