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    Customized Drug Development and Optimize Service

      • • Host Cell DNA (HCD) Detection and Analysis Service

        Residual DNA (rDNA) refers to the aggregate of deoxyribonucleic acid (DNA) and fragments extracted from recombinant host cells, commonly termed as residual host cell DNA. The cell substrates employed in producing biologics like vaccines encompass primary cells, continuously passaged cell lines, and human diploid cells.

      • • Host Cell Protein (HCP) Detection Service

        Biopharmaceuticals, drugs produced by living cells, have revolutionized the treatment of various diseases since Eli Lilly and Company's introduction of the first human recombinant protein, Humulin (human insulin), in 1982. To date, over 200 biopharmaceuticals have been approved, encompassing hormones, growth factors, blood factors, vaccines, and monoclonal antibodies (mAbs), with mAbs being the predominant category.

      • • Antibody Sequencing Service: Advanced NGS and MS Techniques

        Antibodies (Abs) are essential components of the adaptive immune system, which can combat infections and other harmful agents. Produced by B cells, Ab is either secreted or expressed on the plasma membrane at the present of B cell receptors (BCRs). Each Ab comprises two heavy chains (VH) and two light chains (VL). The VL each include a constant region varing only across different classes and subclasses of immunoglobulin (Ig), and a variable region characterized by a sequence of highly variable amino acids a

      • • Protein Corona

        Nanoparticles (NPs), owing to their unique physical, chemical, and biological properties such as controllable size, tunable surface properties, and excellent biocompatibility, have been widely utilized in various fields including cosmetics, food packaging, energy production, and biosensing. Upon release into the environment and subsequent exposure to biological organisms via respiration, ingestion, or dermal penetration, NPs rapidly acquire a protein corona (PC) upon encountering biological fluids.

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