Drug Target Analysis Service

• • Target Identification for Drug Discovery Service

  Target identification for drug discovery focuses on studying the molecular targets of small-molecule drugs. MtoZ Biolabs provides a variety of target identification for drug discovery service combined with experimental methods of LC-MS/MS coupled with TMT labeling or DIA mode. Through rigorous experimental design, precise protein quantification, and advanced bioinformatics analysis, we identify differential protein changes between small molecule-treated and control samples to uncover potential target.

• • Target Identification and Validation Service

  Target identification and validation are critical steps in drug discovery, focusing on identifying molecular targets associated with disease processes and confirming their biological and therapeutic relevance. This process ensures that selected targets play a pivotal role in disease mechanisms, enabling the development of precise and effective therapies. By combining advanced techniques such as genomic and proteomic profiling, functional assays, CRISPR/Cas9 gene editing, and in vivo validation models, targe

• • Targeted Protein Degradation Drugs Characterization Service

  With the rapid development of biotechnology, drug research and development has gradually entered a new era of precision and personalization. Targeted Protein Degradation (TPD) drugs are an emerging therapeutic strategy that utilizes the body's ubiquitin-proteasome system to degrade specific pathological proteins to achieve precise treatment. As an important new class of therapeutic drugs, TPD drugs are attracting more and more attention and innovation.

• • Small Molecule Drug Targets Identification Service | ABPP

  Small molecule drugs play a very important role in the treatment of diseases, and their mechanism of action is to exert their function by interacting with specific target molecules in cells. These target molecules are mainly proteins, including enzymes, ion channel proteins, and other types. Therefore, the identification of the target protein of small molecule drug action is crucial for understanding the mechanism of action and application of small molecule drugs, and can also further discover the off-targe

• • Cryo-Electron Microscopy Based Service

  Structural biology is a field grounded in molecular biology, biochemistry, and biophysics, focusing on the detailed study of biomacromolecules such as proteins and nucleic acids. Its goal is to elucidate the fine structural details of biomacromolecules to understand the mechanisms behind their functional roles, thereby enhancing our understanding of life's processes.

• • HDX Based Protein Conformation Analysis Service

  Hydrogen-deuterium exchange mass spectrometry (HDX-MS) is a mass spectrometry (MS) technique that studies protein spatial conformation. In this process, protein hydrogen atoms can exchange with deuterium atoms in heavy water. The hydrogen atoms of amide bonds on the protein surface or those involved in protein-ligand interactions exchange at a faster rate than those deeper within the protein or not involved in interactions.

• • Molecular Glue Screening Service | PROTAC Service

  Proteins play a pivotal role in the regulation, function, and structure of various human organs and tissues. The regulation of the synthesis and degradation of proteins is crucial for cell functionality. Protein turnover can exist in three states: equilibrium, pool expansion, and pool contraction. At equilibrium, the rate of protein synthesis matches that of degradation, leading to unchanged transcriptome and metabolome profiles.