Methylmalonate Analysis Service
- Qualitative analysis of the metabolites of methylmalonate
- Quantitative analysis of methylmalonate content
- Provide basis for therapeutic research and drug development
Methylmalonate is a key intermediate in the metabolism of certain fatty acids and amino acids, belonging to the family of dicarboxylic acids. It is structurally characterized by a carboxyl group and a methyl group attached to the central carbon atom of the malonate backbone. In mammals, methylmalonate plays a critical role in the metabolic conversion of certain fatty acids and amino acids through its involvement in the methylmalonyl-CoA mutase pathway. This pathway is crucial for the proper metabolism of propionate and odd-chain fatty acids, where methylmalonate is converted into succinyl-CoA. This conversion is an essential step in the citric acid cycle (Krebs cycle), contributing to the production of ATP, the primary energy carrier in cells.
Methylmalonate is also involved in various biological processes, including the regulation of energy metabolism and the synthesis of important metabolic intermediates. Abnormalities in methylmalonate metabolism are linked to several physiological and pathological conditions. For example, elevated levels of methylmalonate can indicate a deficiency in vitamin B12, which is necessary for the proper functioning of methylmalonyl-CoA mutase. Additionally, increased methylmalonate levels have been associated with certain metabolic disorders and neurological conditions. Therefore, the accurate measurement and structural characterization of methylmalonate in biological samples are essential for understanding its role in metabolic disorders and assessing its involvement in disease mechanisms.
Figure 1. The Structure of Methylmalonate
MtoZ Biolabs provides a state-of-the-art Methylmalonate Analysis Service, supported by our robust liquid chromatography-mass spectrometry (LC-MS) platform and a dedicated team of metabolomics experts. Our service ensures a comprehensive methylmalonate analysis with high sensitivity and precision.
Analysis Workflow
Service Advantages
1. Continuously optimized experimental protocols and advanced instrument
2. Professional experimental design
3. Rapid turnaround time
4. High accuracy, specificity, and sensitivity
Applications
Sample Submission Requirements
1. Sample Types
Serum, plasma, urine, tissues, and other biological samples. Each sample should be accompanied by at least 3 control materials under similar conditions.
2. Sample Volume
At least 200 μL of liquid sample; At least 200 mg of solid tissues.
3. Sample Preservation
Samples should be stored at -80°C to ensure their stability.
Note: Provide details on sample collection and handling.
Deliverables
1. Experimental Procedures
2. Relevant Liquid Chromatography and Mass Spectrometry Parameters
3. Detailed Information on Methylmalonate
4. Raw Data
5. Custom Analysis Report
Through our methylmalonate analysis service, we aim to support your research and product development efforts by providing accurate and reliable results.
How to order?
