Propofol Glucuronide Analysis Service

Propofol glucuronide, with molecular formula C₁₈H₂₆O₇. This compound is formed by the glucuronidation of propofol, where the propofol molecule undergoes conjugation with glucuronic acid, resulting in the formation of a glucuronide metabolite. Propofol glucuronide is a major metabolite of propofol, a widely used intravenous anesthetic agent. This metabolite is produced in the liver through the action of the enzyme UDP-glucuronosyltransferase (UGT) during the detoxification and elimination process. Propofol glucuronide is commonly found in the urine and blood of patients following the administration of propofol, and it is an important indicator of the metabolic clearance of the drug. Due to its role in the metabolism of propofol, propofol glucuronide serves as a significant biomarker in pharmacokinetic studies and drug monitoring. 

 

The quantification and analysis of propofol glucuronide in biological samples are typically performed using mass spectrometry (MS) coupled with high-performance liquid chromatography (HPLC). These methods enable precise measurement of propofol glucuronide levels, which is essential for understanding the pharmacokinetics, monitoring drug safety, and optimizing therapeutic strategies in clinical practice.

 



Figure 1. The Structure of Propofol Glucuronide

 

At MtoZ Biolabs, we provide a cutting-edge Propofol Glucuronide Analysis Service which is supported by our advanced liquid chromatography-mass spectrometry (LC-MS) platform and expert metabolomics team. We ensure a comprehensive analysis, maintaining high sensitivity and accuracy.

 

Analysis Workflow

 



 

Service Advantages

1. Continuously optimized experimental protocols and advanced instrument

 

2. Professional experimental design

 

3. Rapid turnaround time

 

4. High accuracy, specificity, and sensitivity

 

Applications

• Qualitative and quantitative analysis of propofol glucuronide
• Determination of propofol glucuronide concentrations in biological samples
• Propofol glucuronide metabolism research

 

Sample Submission Requirements

1. Sample Types

Serum, plasma, urine, tissues and other biological samples. At least 3 materials with the same condition are required for each sample.

 

2. Sample Volume

• Animal tissue ≥ 50 mg
• Plant tissue ≥ 100 mg
• Serum/ Plasma ≥ 100 μL
• Urine ≥ 1 mL

 

3. Sample Preservation

Store at -80°C to maintain stability.

 

Note: Provide details on sample collection and handling.

 

Deliverables

1. Experimental Procedures

2. Relevant Liquid Chromatography and Mass Spectrometry Parameters

3. Detailed Information on Propofol Glucuronide

4. Raw Data

5. Custom Analysis Report

 

With our Propofol Glucuronide Analysis Service, we aim to support your research and product development by providing accurate and reliable data.