Acyl CoAs

Acyl-CoA is a crucial intermediate in fatty acid metabolism, participating in vital biochemical processes such as β-oxidation of fatty acids, lipid synthesis, and energy metabolism. Variations in Acyl-CoA levels and composition can indicate cellular metabolic states, reveal disease mechanisms, and serve as biomarkers for metabolic disorders. Quantitative analysis of Acyl-CoA aids in studying the regulatory mechanisms of lipid and energy metabolism, promoting research into associated diseases and new drug development.

 



Figure 1. General Chemical Structure of an Acyl-CoA

 

MtoZ Biolabs offers specialized Acyl-CoA analysis services, combining advanced mass spectrometry technology with cutting-edge bioinformatics tools to deliver accurate and reliable quantitative analysis of Acyl-CoA, supporting scientific research and applications.

 

Analysis Workflow

 



 

Services at MtoZ Biolabs

Palmitoyl-CoA

Palmitoleoyl-CoA

Stearoyl-CoA

Oleoyl-CoA

Linoleoyl-CoA

Arachidyl-CoA

Arachidonyl-CoA

Behenyl-CoA

Lignoceryl-CoA

Cerotyl-CoA

 

Service Advantages

• High Sensitivity and Specificity: Utilize high-resolution mass spectrometry instruments and optimized chromatographic conditions to ensure precise identification and quantification of Acyl-CoA.
• Comprehensive Metabolite Coverage: Detect and analyze various Acyl-CoA molecules, providing a detailed metabolic profile.
• Dynamic Change Analysis: Monitor Acyl-CoA level changes under different conditions, uncovering regulatory mechanisms.
• Efficient Data Analysis: Employ professional data analysis platforms to deliver comprehensive Acyl-CoA information and interpret its biological significance.

 

Applications

Disease Mechanism Research: Investigate the molecular mechanisms of metabolic diseases (e.g., diabetes, obesity, cardiovascular diseases) through Acyl-CoA analysis.

 

Biomarker Discovery: Identify and validate Acyl-CoA as potential biomarkers for metabolic disorders.

 

Drug Development: Assess the impact of drugs on Acyl-CoA metabolism, supporting drug screening and target validation.

 

Nutrition and Metabolism Research: Explore the effects of different nutritional states on Acyl-CoA metabolism, elucidating its role in energy metabolism.

 

Deliverables

1. Experimental Procedures

2. Relevant Liquid Chromatography and Mass Spectrometry Parameters

3. Detailed Information on Acyl-CoAs

4. Raw Data

5. Custom Analysis Report