Single Cell Analysis Service

In multicellular systems, diverse cell types coexist and coordinate distinct functions. Traditional bulk omics approaches often mask the heterogeneity between cells, providing only averaged measurements. This limitation is especially pronounced in complex biological contexts such as the tumor microenvironment, immune responses, or neural circuits—where rare but functionally critical cell subtypes may be overlooked.

 



Ye, F. et al. J HEMATOL ONCOL. 2017.

Figure 1. Single-Cell Analysis Reveals Heterogeneity

 

MtoZ Biolabs’ Single Cell Analysis Service offers an integrated, multi-omics workflow that spans transcriptomics, proteomics, epigenomics, spatial omics, and immune repertoire profiling. Powered by advanced platforms including 10x Genomics, Orbitrap Astral, timsTOF HT, and CyTOF, we deliver full-process solutions from single-cell isolation to biological insight. Our service is designed to support both fundamental research and clinical translational studies that demand cellular resolution.

 

Services at MtoZ Biolabs

MtoZ Biolabs offers a suite of modular services under the Single Cell Analysis Service, tailored to diverse scientific objectives:

• Single-cell Sequencing Service

One-stop service from cell isolation to data analysis for scRNA-seq, scATAC-seq, and sc-methylation. Enables the dissection of rare subtypes, lineage tracing, and epigenetic state discovery.

 

• Single Cell Mass Cytometry Analysis

CyTOF-based multiplexed protein expression analysis for immune phenotyping, functional status tracking, and population clustering.

 

• Single-Cell Transcriptomics Service

Using the 10x Genomics + Illumina pipeline, we quantify both mRNA and non-coding RNA expression per cell, supporting pseudotime inference and cross-sample comparison in developmental, oncogenic, or immunological models.

 

• Single Cell Spatial Transcriptomics Service

Preserves spatial information of cells within tissue slices to map cellular neighborhood interactions, tumor microenvironments, and developmental zones.

 

• Single-Cell Proteomics Analysis

Using Orbitrap Astral and timsTOF HT, we analyze proteome composition and modification states in individual cells. Particularly suitable for low-input systems such as early embryonic stages, immune activation, or drug response profiling.

 

• 10x TCR Sequencing Service/ 10x BCR Sequencing Service

Enables full-length paired receptor profiling from single T or B cells to study clonal expansion, immune surveillance, or immunotherapy response.

 

• Single Cell Methylation Sequencing Service

High-resolution epigenetic mapping at the single-cell level to explore cell-specific regulatory networks in embryogenesis, cancer, or neurodegenerative diseases.

 

Experimental Instruments

Our Single Cell Analysis Service is built on best-in-class instrumentation to support every phase from cell capture and library construction to deep omics profiling:

 



 

Why Choose MtoZ Biolabs?

✅ Multi-Omics Platform Integration

Seamless data generation across transcriptomic, proteomic, epigenomic, and spatial layers to support systems-level interpretation.

 

✅ Full In-House Workflow with Consistent Quality Control

From sample handling to library construction, sequencing, and bioinformatics—all steps are completed internally for high reproducibility.

 

✅ Versatile Sample Preparation Options

FACS sorting, microfluidic capture, and enzymatic digestion tailored to sample type—including tumor biopsies, immune cells, or low-input suspensions.

 

✅ Publication-Ready Bioinformatics Output

Cell clustering, trajectory inference, functional annotation, pathway enrichment, and customizable visualization modules aligned with SCI publishing standards.

 

✅ Proven Track Record with Complex Samples

Extensive experience handling FFPE sections, dissociated tumor samples, immune-enriched populations, and low-viability specimens.

 

Sample Submission Suggestions

 



 

Need help preparing your samples? Our technical experts will provide customized protocols and logistics support based on your research goals.

 

What Could be Included in the Report?

1. Project Workflow Overview

2. Platform and Reagent Summary

3. QC Reports and Cell Recovery Statistics

4. Gene Expression Matrices and UMAP/t-SNE Plots

5. Functional Annotation and Enrichment Analyses

6. Raw FASTQ files and Meta-Data Sheets

 

MtoZ Biolabs’ Single Cell Analysis Service empowers researchers to uncover biological complexity at single-cell resolution—transforming how we understand cellular behavior in health and disease.

 

Contact us today to design your single-cell discovery pipeline.