γ-Glutamate-Cysteine Analysis Service

γ-L-Glutamyl-L-Cysteine (γ-L-Glu-L-Cys), also known as γ-Glutamylcysteine (GGC), is a dipeptide commonly found in animals, plants, fungi, bacteria, and archaea. As a precursor to glutathione, it is crucial for cellular redox balance and detoxification. The synthesis of glutathione begins with γ-L-Glu-L-Cys, which is essential for maintaining cellular functions and protecting against oxidative stress by influencing antioxidant capacity and signal transduction. γ-L-Glu-L-Cys possesses distinct biological functions and metabolic properties compared to its precursor amino acids and participates in various metabolic pathways. Its diverse roles in both physiological and pathological states make accurate analysis of its concentration vital for understanding its functions and metabolic pathways in organisms.

 

 

Figure 1. Molecular Structure of γ-L-Glu-L-Cys

 

MtoZ Biolabs utilizes liquid chromatography-tandem mass spectrometry (LC-MS/MS) to conduct detailed quantitative and qualitative analyses of γ-L-Glu-L-Cys and its metabolites. This advanced method integrates LC's rapid separation capabilities with the high detection sensitivity of MS/MS, facilitating the precise measurement of γ-L-Glu-L-Cys in complex biological matrices.

 

Analysis Workflow

 

 

 

Service Advantages

1. High Sensitivity and Precision

HPLC-MS/MS provides highly sensitive and accurate measurements, suitable for detecting low concentrations of γ-L-Glu-L-Cys and differentiating its isomers.

 

2. Rapid and Efficient

Optimized sample preparation and fast analysis ensure quick and efficient processing.

 

3. Wide Applicability

Suitable for various biological samples, including blood, urine, and tissues.

 

4. Accurate and Reliable Data

Ensures high reproducibility and low error rates, supporting both research and clinical applications, providing reliable and specific results.

 

Sample Submission Requirements

 



For detailed sample submission instructions, please consult our technical team.

 

Applications

Clinical Diagnosis: Measure γ-L-Glu-L-Cys levels in patients with oxidative stress, chronic inflammation, and metabolic disorders to assist in diagnosis and prognosis.

 

Metabolic Research: Investigate the roles of γ-L-Glu-L-Cys in antioxidant defense, detoxification, and intracellular redox balance.

 

Drug Development: Evaluate the impact of drugs on γ-L-Glu-L-Cys metabolism to aid in developing new therapeutic agents.

 

Nutritional Research: Analyze the metabolic changes of γ-L-Glu-L-Cys under different dietary conditions, providing scientific evidence for nutritional regulation and dietary supplementation.

 

Deliverables

1. Experimental Procedures

2. Relevant Liquid Chromatography and Mass Spectrometry Parameters

3. Detailed Information on γ-L-Glu-L-Cys and their Metabolites

4. Raw Data

5. Custom Analysis Report

 

MtoZ Biolabs is dedicated to advancing your research and clinical projects by providing detailed insights into γ-L-Glu-L-Cys's extensive physiological roles through top-tier analytical techniques and expert services.