2-Methoxyestrone Analysis Service
- Uncovering new biomarkers for disease
- Improving disease diagnosis
- Accelerating the discovery of innovative therapeutics
- Providing new insights into disease mechanisms
- Animal tissue ≥ 100 mg
- Plant tissue ≥ 200 mg
- Serum/ Plasma ≥ 200 μL
- Urine ≥ 2 mL
2-Methoxyestrone (chemical formula C19H24O3) is a steroid estrogen derivative and a metabolite of estrone. Its structure consists of a typical steroid skeleton with four carbon rings (A, B, C, D rings), similar to other estrogen molecules. The main feature of 2-methoxyestrone is a methoxy group (-OCH₃) at the 2nd carbon position, which significantly differs from estrone, where a hydroxyl group (-OH) is typically found at this position. The biological activity of 2-methoxyestrone is weaker compared to its parent compound, estrone. It is considered a less biologically active estrogen metabolite and does not activate estrogen receptors as strongly as estrone or estradiol. However, studies have shown that 2-methoxyestrone may still play an important regulatory role under certain physiological conditions. It may possess anti-estrogenic properties, potentially inhibiting the growth of estrogen-dependent tumors, such as breast cancer, by lowering the levels of more potent estrogens like estradiol. Additionally, 2-methoxyestrone may help maintain estrogen balance in the body, reduce the production of reactive oxygen species (ROS) during estrogen metabolism, and modulate inflammatory responses. The metabolites of 2-methoxyestrone generally exhibit lower estrogenic activity, making them part of the feedback mechanism that regulates estrogen levels in the body. These metabolites may decrease the overall estrogenic effect and provide protective effects in certain estrogen-related diseases, such as endometriosis or breast cancer. Research also suggests that these metabolites may have anti-inflammatory and antioxidant functions, helping reduce free radical formation and oxidative stress, especially in pathological conditions related to excessive estrogen activity.
Measuring the levels of 2-methoxyestrone and its metabolites in plant and biological samples holds significant biomedical and environmental research importance. In biological samples, the levels of 2-methoxyestrone can reflect an individual's estrogen metabolism status, particularly in research related to estrogen-dependent tumors, such as breast cancer and endometrial cancer, where it has diagnostic and prognostic value. Furthermore, analyzing changes in 2-methoxyestrone and its metabolites in the body can provide insights into endocrine function changes across different genders and age groups, particularly regarding the fluctuating estrogen levels during perimenopause and postmenopause and their impact on health. The application of highly sensitive techniques such as mass spectrometry enables precise quantification of 2-methoxyestrone and its metabolites. This is crucial for exploring the mechanisms underlying estrogen metabolism disorders, developing new therapeutic strategies, and monitoring the effects of hormone pollutants in the environment.
Figure 1. The Structure of 2-Methoxy Estrone
MtoZ Biolabs, an integrated chromatography and mass spectrometry (MS) services provider, providing advanced metabolomics, proteomics and biopharmaceutical analysis services to researchers in biochemistry, biotechnology, and biopharmaceutical fields. Our ultimate aim is to provide more rapid, high-throughput, and cost-effective analysis, with exceptional data quality and minimal sample consumption. MtoZ Biolabs utilizes an LC-MS-based metabolomics research platform for the analysis of 2-methoxyestrone. We ensure the accuracy of the quantification of 2-methoxyestrone and its metabolites, as well as the comprehensiveness and precision of metabolite identification. If you are interested in our 2-methoxyestrone analysis service, please feel free to contact us at any time, and we will be fully committed to providing you with high-quality analytical services and technical support.
Analysis Workflow
Service Advantages
1. Advance Analysis Platform: MtoZ Biolabs established an advanced 2-methoxyestrone analysis platform, guaranteeing reliable, fast, and highly accurate analysis service.
2. One-Time-Charge: Our pricing is transparent, no hidden fees or additional costs.
3. High-Data-Quality: Extensive data coverage with rigorous quality control. Our advanced analysis platform consolidates all 2-methoxyestrone analysis data, delivering clients a detailed and comprehensive data report.
4. Quick Turnaround: We offer a fast analysis process to ensure that clients receive high-quality data within a short time.
Applications
Sample Submission Requirements
1. Sample Types
Serum, plasma, urine, tissues and other biological samples. For each sample, it is required to select more than 3 materials under the same condition.
2. Sample Volume
3. Sample Preservation
Store samples at -80°C to maintain stability.
Note: Please provide details on sample collection and handling.
Deliverables
1. Experimental Procedures
2. Relevant Liquid Chromatography and Mass Spectrometry Parameters
3. Detailed Information on 2-Methoxyestrone
4. Raw Data
5. Custom Analysis Report
With our 2-methoxyestrone analysis service, we strive to support your research and product development processes by delivering accurate and reliable results.
How to order?
