21-Deoxycortisol Analysis Service

21-Deoxycortisol also known as 11β,17α-dihydroxyprogesterone or as 11β,17α-dihydroxypregn-4-ene-3,20-dione, is a steroid hormone synthesized by the adrenal cortex, playing a critical role as an intermediate in cortisol synthesis. It serves as a key marker for 21-hydroxylase deficiency, a condition where 21-deoxycortisol cannot be converted into cortisol or other essential glucocorticoids. This metabolic blockage leads to its accumulation in the bloodstream, which is closely linked to congenital adrenal hyperplasia (CAH). Measuring 21-deoxycortisol levels is crucial for the clinical diagnosis and management of CAH, as well as for understanding the pathophysiology and treatment responses in adrenal disorders.

 

Figure 1. Molecular Structure of 21-Deoxycortisol

 

MtoZ Biolabs offers 21-Deoxycortisol Analysis Service using high performance liquid chromatography-mass spectrometry (HPLC-MS). This advanced method combines the separation capabilities of HPLC with the detection power of MS, ensuring high sensitivity and specificity in 21-deoxycortisol detection.

 

Analysis Workflow

 



 

Service Advantages

• Rapid Analysis Cycle and Cost-Effectiveness
• Stable, Reliable, and Highly Sensitive Results
• Comprehensive One-Stop Service for Extensive Testing Needs
• User-Friendly Operation with Wide Application Scope
• Supported by Extensive Bioanalytical Resources and Advanced Platforms

 

Sample Submission Requirements

1. Sample Types

Serum, plasma, urine, tissue extracts, and other biological samples.

 

2. Sample Volume

At least 200 μL of liquid sample or 200 mg of solid sample.

 

3. Sample Preservation

Store samples at -20°C or lower to prevent degradation, avoiding repeated freeze-thaw cycles.

 

Note: Provide details on sample collection and handling.

 

Applications

• Hormonal Research
• Pharmacological Studies
• Therapeutic Monitoring
• Clinical Diagnostics

 

Deliverables

1. Experimental Procedures

2. Relevant Liquid Chromatography and Mass Spectrometry Parameters

3. Detailed Information on 21-Deoxycortisol

4. Raw Data

5. Custom Analysis Report

 

MtoZ Biolabs is dedicated to advancing your research and clinical projects by providing detailed insights into 21-deoxycortisol's extensive physiological roles through top-tier analytical techniques and expert services.