6PG Analysis Service

6-Phosphogluconate (6PG) is a key intermediate in the pentose phosphate pathway (PPP), a crucial metabolic pathway that operates parallel to glycolysis. Chemically, 6PG is a six-carbon sugar phosphate derived from glucose-6-phosphate and is involved in the oxidative phase of the PPP. This pathway is vital for generating reducing power in the form of NADPH and providing ribose-5-phosphate for nucleotide synthesis, both of which are essential for cellular growth and maintenance.

 

The pentose phosphate pathway plays a significant role in cellular metabolism by protecting cells against oxidative stress and contributing to the biosynthesis of nucleotides and nucleic acids. The enzyme 6-phosphogluconate dehydrogenase catalyzes the conversion of 6PG to ribulose-5-phosphate, a reaction that is critical for maintaining the balance between NADPH production and oxidative stress management. Disruptions in this pathway can lead to imbalances in cellular redox states and contribute to various diseases, including cancer, diabetes, and neurodegenerative disorders.

 

Research into 6PG and the pentose phosphate pathway has gained importance due to its implications in metabolic disorders and its potential as a therapeutic target. Understanding the levels and metabolism of 6PG can provide insights into the physiological and pathological conditions that affect cellular metabolism and contribute to disease progression.

 



 

Figure 1. The Structure of 6PG

 

At MtoZ Biolabs, we offer a comprehensive 6PG analysis service using advanced LC-MS/MS platforms. We are fully equipped to handle diverse sample types and deliver highly accurate and reliable results quickly.

 

Analysis Workflow

 



 

Service Advantages

• Highly Efficient Sample Recovery and Processing
• Accurate and Reliable Detection and Quantification
• Capability to Handle Various Sample Types
• Customized Data Analysis Services
• Rapid Service Response and Cost-Effectiveness

 

Applications

Our 6PG analysis service can be used in a wide range of applications including:

• Disease biomarker discovery
• Drug metabolism studies
• Metabolic pathway studies

 

Sample Submission Requirements

1. Sample Types

Serum, plasma, urine, tissues, and other biological samples.

 

2. Sample Volume

• Animal tissue ≥ 100 mg
• Plant tissue ≥ 200 mg
• Serum/ Plasma ≥ 200 μL
• Urine ≥ 2 mL

 

3. Storage and Shipping

Samples should be stored at -80℃ and shipped with dry ice.

 

Note: Please provide details on sample collection and handling.

 

Deliverables

1. Experimental Procedures

2. Relevant Liquid Chromatography and Mass Spectrometry Parameters

3. Detailed Information on 6PG

4. Raw Data

5. Custom Analysis Report

 

At MtoZ Biolabs, we are dedicated to providing high-quality metabolomics analysis services. Contact us today to learn how our 6PG analysis service can help advance your research.