7-methyl-6-thioguanosine Analysis Service

7-methyl-6-thioguanosine (m7G) is a modified nucleoside that originates from transfer RNA (tRNA). It's a significant component of the "wobble" position in the anticodon loop of tRNA, contributing to the precise recognition of codons during protein synthesis. Structurally, it possesses a methyl group at position 7 and sulfur atom at position 6. Studies have demonstrated that m7G is involved in various metabolic processes and plays essential roles in cell proliferation, differentiation, and survival.

 



 

Figure 1. The Structure of 7-methyl-6-thioguanosine

 

Alterations in the level of 7-methyl-6-thioguanosine have been linked to several diseases, including cancer, autoimmune diseases and neurological disorders. Therefore, understanding the distribution, metabolism, and function of m7G can provide important insights into the pathogenesis of these diseases and may lead to the discovery of new therapeutic targets.

 

At MtoZ Biolabs, we offer a comprehensive 7-methyl-6-thioguanosine analysis service, utilizing advanced mass spectrometry techniques to deliver accurate and reliable results. We can assist our clients in:

• Monitoring the levels of 7-methyl-6-thioguanosine in various biological samples.
• Studying the role of 7-methyl-6-thioguanosine in metabolic processes.
• Investigating the potential correlation between 7-methyl-6-thioguanosine levels and disease progression.

 

Analysis Workflow

 



 

Service Advantages

• Extensive expertise in handling various biological samples and extracting metabolites.
• State-of-the-art mass spectrometry platforms.
• Strict quality control to ensure reliable results.
• Comprehensive statistical and bioinformatics analysis.
• Personalized service to meet various research needs.

 

Applications

Our 7-methyl-6-thioguanosine analysis service is valuable for researchers studying:

• tRNA modifications and their roles in cell metabolism.
• The association between 7-methyl-6-thioguanosine and various diseases.
• The potential of 7-methyl-6-thioguanosine as a biomarker for disease diagnosis or prognosis.

 

Sample Submission Requirements

 



 

• Samples should be stored at -80℃ and shipped with dry ice.
• It is necessary to prepare more than 3 biological replicates for each type of sample.
• Please provide details on sample collection and handling.
• Other sample types, please contact us for more details.

 

Deliverables

1. Experimental Procedures

2. Relevant Liquid Chromatography and Mass Spectrometry Parameters

3. Detailed Information on 7-methyl-6-thioguanosine

4. Raw Data

5. Custom Analysis Report

 

For more information on our 7-methyl-6-thioguanosine analysis service, please contact us.