9,15-dioxo-11R-hydroxy-5Z,13E-prostadienoic Acid Analysis Service
- Quantitative analysis of 9,15-dioxo-11R-hydroxy-5Z,13E-prostadienoic acid in various samples
- Comprehensive metabolite profiling to elucidate metabolic pathways
- Insights into disease mechanisms and biomarker discovery
- Drug metabolism and pharmacokinetics studies
- Biomarker discovery
- Study of disease mechanisms
- Nutritional research
- Animal tissue ≥ 100 mg
- Plant tissue ≥ 200 mg
- Serum/ Plasma ≥ 200 μL
- Urine ≥ 2 mL
9,15-Dioxo-11R-hydroxy-5Z,13E-prostadienoic acid, also known as 15-keto-Prostaglandin E2 (15-keto-PGE2), is an endogenous metabolite derived from the degradation of Prostaglandin E2 (PGE2), a key mediator in inflammation and immune regulation. 15-keto-PGE2 contains two oxo groups at positions 9 and 15, a hydroxyl group at position 11, and conjugated double bonds at 5Z and 13E, contributing to its potent biological activities.
15-keto-PGE2 is recognized for its ability to modulate various cellular signaling pathways. It inhibits the activation of the STAT3 pathway by binding to the Cys259 residue of STAT3, a transcription factor known to promote tumor progression and inflammation. Additionally, 15-keto-PGE2 stabilizes the EP2 and EP4 receptors, both of which are involved in mediating the effects of prostaglandins on vasodilation, immune responses, and cell proliferation. Moreover, 15-keto-PGE2 activates peroxisome proliferator-activated receptor gamma (PPAR-γ), a nuclear receptor that regulates lipid metabolism, inflammation, and cell differentiation. This activation has been associated with promoting fungal growth, indicating its broader biological effects beyond its role in inflammation. Importantly, 15-keto-PGE2 has demonstrated anti-cancer properties, particularly in inhibiting breast cancer cell growth and progression. Its ability to regulate inflammatory signaling, immune responses, and cellular proliferation makes it a promising target for therapeutic research, particularly in cancer and inflammatory disease contexts.
Figure 1. The Structure of 9,15-dioxo-11R-hydroxy-5Z,13E-prostadienoic Acid
Given its significant biological impact and potential therapeutic applications, the precise quantification and characterization of 15-keto-PGE2 are critical for advancing research in cancer, inflammation, and metabolic disorders. MtoZ Biolabs, an integrated Chromatography and Mass Spectrometry (MS) Services Provider, provides advanced proteomics, metabolomics, and biopharmaceutical analysis services to researchers in biochemistry, biotechnology, and biopharmaceutical fields. Our ultimate aim is to provide more rapid, high-throughput, and cost-effective analysis, with exceptional data quality and minimal sample consumption. MtoZ Biolabs now offers a comprehensive 9,15-Dioxo-11R-hydroxy-5Z,13E-prostadienoic Acid Analysis Service, leveraging advanced mass spectrometry technology to deliver accurate and reliable analytical results.
At MtoZ Biolabs, we specialize in providing comprehensive metabolomics services. Our 9,15-dioxo-11R-hydroxy-5Z,13E-prostadienoic acid analysis service can offer:
Analysis Workflow
Service Advantages
1. Advance Analysis Platform
MtoZ Biolabs established an advanced 9,15-dioxo-11R-hydroxy-5Z,13E-prostadienoic acid analysis service platform, guaranteeing reliable, fast, and highly accurate analysis service.
2. One-Time-Charge
Our pricing is transparent, no hidden fees or additional costs.
3. High-Data-Quality
Deep data coverage with strict data quality control. AI-powered bioinformatics platform integrate all 9,15-dioxo-11R-hydroxy-5Z,13E-prostadienoic acid analysis service data providing clients with a comprehensive data report.
4. Fast Turnaround
The process from sample handling to report generation is efficient, shortening the analysis cycle.
Applications
Our service can be applied in various fields, including:
Sample Submission Requirements
1. Sample Types
Serum, plasma, urine, tissues, and other biological samples. It is recommended to prepare at least 3 biological replicates for each sample type.
2. Sample Volume
3. Storage and Shipping
Samples should be stored at -80℃ and shipped with dry ice. Avoid repeated cycles of freezing and thawing
Note: Please provide details on sample collection and handling.
Deliverables
1. Comprehensive Experimental Details (Materials, Instruments, and Methods, etc.)
2. Relevant Liquid Chromatography and Mass Spectrometry Parameters
3. Detailed Information on 9,15-dioxo-11R-hydroxy-5Z,13E-prostadienoic Acid
4. Raw Data
5. Custom Analysis Report
At MtoZ Biolabs, we're dedicated to providing accurate and reliable analysis to support your research. Contact us today to learn more about our 9,15-dioxo-11R-hydroxy-5Z,13E-prostadienoic acid analysis service.
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