SEC Based Molecular Size Variation Analysis Service

Molecular size variability critically influences the properties of biomacromolecules such as proteins, antibodies, and peptides, especially in the realms of drug research and bioproduct manufacturing. Size exclusion chromatography (SEC), also known as gel permeation chromatography (GPC), separates compounds based on molecular size. This method leverages the size exclusion effect of column packing pores, allowing molecules of different sizes to traverse the chromatography column at varying rates to achieve separation. The relative molecular size of the sample is estimated by comparing the elution order of the sample with standard proteins of known size.

 



Figure 1. Analysis of Molecular Size Variability via SEC

 

The SEC-based molecular size variability analysis at MtoZ Biolabs offers insights into the size, molecular weight, and distribution of molecules in samples, serving as an essential tool in drug quality control, vaccine development, and enzyme activity studies. Leveraging an advanced SEC system and high-sensitivity detectors, MtoZ Biolabs has developed an efficient analysis platform to provide thorough and accurate SEC molecular size variability analyses. With expert data processing and interpretation, this platform ensures that all quality aspects of protein or peptide products are met during both research and production phases. MtoZ Biolabs swiftly delivers comprehensive solutions and data support for all molecular forms, from high molecular weight aggregates and medium molecular weight target proteins to low molecular weight degradation products.

 

Deliverables

In the technical report, MtoZ Biolabs will provide you with detailed technical information, including:

1. Experimental Procedures

2. Relevant Experimental Parameters

3. Detailed Information on SEC-Based Molecular Size Variability Analysis

4. Electrophoresis Images

5. Raw Data