Biopharmaceutic Characterization FAQ

• • What Do Ratio, DL, and BEC Mean in ICP-MS Trace Element Analysis

  In ICP-MS (Inductively Coupled Plasma Mass Spectrometry) trace element analysis, "Ratio," "DL," and "BEC" are key terms. Below are their definitions: 1. Ratio In ICP-MS analysis, the ratio typically refers to the signal of a specific element in a sample relative to the signal of an internal standard. The internal standard is an element of known concentration added to all samples and standards to correct for potential signal fluctuations during sample preparation or analysis. Using ratios helps minimize.....

• • What Are the Advantages of Biologics Over Chemical Small Molecule Drugs, and What Are the Challenges in Their Development?

  Biologics offer several distinct advantages compared to chemical small molecule drugs, although there are also significant challenges associated with their development.   Advantages 1. High Specificity Biologics typically exhibit strong specificity, allowing them to target particular pathological molecules, such as proteins, peptides, and polysaccharides, which enables more precise therapeutic intervention.   2. Reduced Toxicity Due to their high specificity, biologics generally minimize their effects......

• • In What Is DTNB Dissolved? Is the Solution Neutral or Alkaline During Thiol Group Testing?

  DTNB (5,5'-dithiobis(2-nitrobenzoic acid), commonly referred to as Ellman's reagent) is typically dissolved in ethanol or water. During thiol group testing, the reaction of DTNB usually takes place in a near-neutral or slightly alkaline environment. This pH range is optimal because it enhances the reactivity of the thiol group with DTNB.   MtoZ Biolabs, an integrated chromatography and mass spectrometry (MS) services provider. Related Services Free Sulfhydryl Quantification Service