Cyclic Peptide Synthesis Service
- Drug Development: Enables the creation of antibiotics, anticancer agents, and enzyme inhibitors.
- Target Validation: Employs cyclic peptides to explore protein-protein interactions and validate molecular targets.
- Diagnostics: Develops biomarkers and imaging tools for disease monitoring.
- Biological Research: Advances understanding of peptide structure-function relationships.
- Material Science: Utilizes cyclic peptide properties to innovate in nanomaterials and biofunctional materials.
Cyclic peptide synthesis is a pivotal approach for constructing cyclic peptides via chemical or biological methods. This process often employs solid-phase synthesis combined with various cyclization reactions—such as amide bond formation, disulfide bridging, or hydrocarbon stapling. These techniques significantly enhance the conformational stability of cyclic peptides, reduce their susceptibility to protease degradation, and improve their target-binding affinity. These attributes make cyclic peptides indispensable tools in modern biomedical research.
Yan, L. Z. et al. Tetrahedron Lett. 2004.
Figure 1. Schematic Diagram of Cyclic Peptide Synthesis
Cyclic peptides exhibit remarkable structural diversity, ranging from monocyclic to bicyclic and tricyclic forms, with each type offering unique functional properties. For instance, monocyclic peptides mimic the structure and function of natural bioactive peptides, making them valuable in basic biological research. On the other hand, the complex spatial conformations of bicyclic and tricyclic peptides enable them to play critical roles in inhibiting protein-protein interactions and supporting small-molecule drug development. Prominent examples such as Chitinamide B, Tryptorubin A, and PCSK9 inhibitors highlight the therapeutic potential of cyclic peptides in drug discovery.
Liu, H. P. et al. Tetrahedron Lett. 2024.
Figure 2. Diversity of Cyclic Peptides
Leveraging advanced synthesis platforms and a team of seasoned professionals, MtoZ Biolabs provides comprehensive cyclic peptide synthesis service. From design to purification, we offer one-stop solutions tailored to diverse research needs, ensuring reliable technical support that drives scientific breakthroughs.
Services at MtoZ Biolabs
MtoZ Biolabs specializes in cyclic peptide synthesis using a wide range of cyclization methods tailored to diverse research needs:
1. Head-to-Tail Cyclization
Constructs stable cyclic peptides by forming amide bonds between the peptide chain's N- and C-termini. This method is ideal for drug development and protein target studies.
2. Side-Chain Cyclization
Forms lactam bridges between specific side chains, such as lysine or glutamic acid, to enhance structural specificity and reduce enzymatic degradation.
3. Disulfide Bridge Cyclization
Introduces cysteine residues to form disulfide bonds, replicating natural bioactive peptide conformations for advanced biological research.
4. Hydrocarbon Stapling
Creates α-helical structures that mimic protein interaction sites, improving intracellular targeting and molecular stability.
5. Multicyclic Peptide Design
Offers custom synthesis of bicyclic and tricyclic peptides, supporting complex molecular function exploration.
Service Advantages
MtoZ Biolabs is committed to delivering efficient and precise cyclic peptide synthesis service supported by diverse synthesis methods, professional technical assistance and stringent quality control to meet various research demands. Our core advantages include:
1. Precise Design and Optimization
Offers peptide design support, including sequence optimization, structural modifications, and modification strategies, ensuring scientifically sound designs that meet research needs.
2. High-Quality Synthesis
Combines chemical and biological synthesis techniques, optimizing cyclization conditions to deliver peptides with over 95% purity, suitable for high-standard scientific applications.
3. Comprehensive Quality Assurance
Ensures peptide purity and structural accuracy through high-resolution mass spectrometry and HPLC testing at every production stage, meeting strict quality requirements.
4. Flexible Scale Production
Supports production scales ranging from milligrams to hundreds of grams, catering to diverse needs from basic research and pilot studies to industrial applications.
5. Diverse Modification Services
Offers additional functionalization services, including fluorescent labeling and site-specific modifications, expanding the application potential of cyclic peptides for complex research scenarios.
Applications
Case Study
Case1
A range of cyclic peptides with high stability and notable biological activity were successfully synthesized and selected using cyclic peptide synthesis technology. Some of these peptides showed more than 50% oral absorption in vivo. The distinctive cyclic structure of these peptides not only ensures strong enzymatic stability but also enhances their biological activity, positioning them as valuable candidates for small molecule drug development. This study underscores the key role of the cyclic peptide synthesis service in accurately synthesizing complex cyclic peptide structures, improving their stability, and boosting their drug development potential, thus providing robust technical support for the creation of new oral medications.
Merz, M. L. et al. Nat Chem Biol. 2024.
Case2
By integrating cyclic peptide synthesis with gold(I)-catalyzed macrocyclization, this research successfully developed several cyclic peptides with fluorescent properties, demonstrating the advantages of their unique cyclic structures in improving both chemical stability and functionality. These fluorescent cyclic peptides show great promise for use in biological imaging and molecular probes, offering significant support for the advancement of innovative diagnostic tools.
Liu, X. Y. et al. J. Am. Chem. Soc. 2023.
FAQ
Q1: How does MtoZ Biolabs address challenges in multicyclic peptide design?
Multicyclic peptide design involves multiple cyclization sites, which may lead to site competition or side reactions. MtoZ Biolabs ensures efficient cyclization at each step by employing selective protecting group techniques, precise deprotection control, and stepwise cyclization strategies. Furthermore, our separation and purification technologies eliminate potential byproducts, ensuring structural integrity and functional reliability of multicyclic peptides.
MtoZ Biolabs focuses on providing high-quality cyclic peptide synthesis service with professional expertise and rigorous quality control to meet research needs. We are dedicated to helping customers address challenges in cyclic peptide-related studies and advancing projects successfully. Contact us to learn more about cyclic peptide synthesis solutions.
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