DL-Kynurenine Analysis Service
- Highly Efficient Sample Recovery and Processing
- Accurate and Reliable Detection and Quantification
- Capability to Handle Various Sample Types
- Customized Data Analysis Services
- Rapid Service Response and Cost-Effectiveness
- Tryptophan Metabolism Studies: Analyze kynurenine pathway intermediates in tryptophan degradation.
- Neuroinflammation Research: Investigate DL-Kynurenine's role in neurodegenerative disease mechanisms.
- Biomarker Discovery: Identify DL-Kynurenine as a potential biomarker in disease diagnostics.
- Psychiatric Disorder Research: Study its role in mood disorders like depression and schizophrenia.
- Pharmacological Testing: Evaluate drug effects on kynurenine pathway activity.
- Animal tissue ≥ 100 mg
- Plant tissue ≥ 200 mg
- Serum/ Plasma ≥ 200 μL
- Urine ≥ 2 mL
DL-Kynurenine is a racemic mixture of two stereoisomers, L-Kynurenine and D-Kynurenine, both of which play distinct roles in biological systems. L-Kynurenine is the biologically active form found in the kynurenine pathway, which is critical in several physiological processes, including immune modulation and neuroinflammation. In contrast, D-Kynurenine is less prevalent in nature but still holds significant research interest due to its potential involvement in pathophysiological conditions and its role as a neuroprotective agent in certain contexts.
The kynurenine pathway is the primary route of tryptophan degradation and generates metabolites that influence neurodegenerative diseases, immune responses, and cancer progression. DL-Kynurenine, as a key intermediate, has been implicated in various disorders such as depression, schizophrenia, and Alzheimer's disease. Its role in regulating immune tolerance, particularly through interactions with enzymes like indoleamine 2,3-dioxygenase (IDO), has attracted attention in cancer immunotherapy and autoimmune disease research. Moreover, kynurenine pathway dysregulation is increasingly recognized as a significant contributor to oxidative stress, excitotoxicity, and neuronal damage, making DL-Kynurenine an important focus in neuroinflammatory and psychiatric research.
Research into DL-Kynurenine is crucial for understanding the broader kynurenine pathway and its metabolites, many of which serve as potential biomarkers for disease states. As kynurenine metabolism becomes increasingly linked to critical physiological and pathological processes, accurate and sensitive measurement of DL-Kynurenine is essential for advancing clinical and translational research. MtoZ Biolabs offers state-of-the-art DL-Kynurenine Analysis Services, utilizing advanced mass spectrometry techniques to provide comprehensive, accurate data to support research in this vital biochemical pathway.
Analysis Workflow
Service Advantages
Applications
Sample Submission Requirements
1. Sample Types
Serum, plasma, urine, tissues, and other biological samples. A minimum of 3 materials with the same condition is required for each sample.
2. Sample Volume
3. Sample Preservation
Samples should be stored at -80°C to maintain stability.
Note: Please provide detailed information about sample collection and handling procedures.
Deliverables
1. Experimental Procedures
2. Relevant Liquid Chromatography and Mass Spectrometry Parameters
3. Detailed Information on DL-Kynurenine
4. Raw Data
5. Custom Analysis Report
For any further information or inquiry regarding our DL-Kynurenine Analysis Service, please feel free to contact us. Here at MtoZ Biolabs, we are committed to providing high-quality data for your research.
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