Fumarate Analysis Service
- Highly Efficient Sample Recovery and Processing
- Accurate and Reliable Detection and Quantification
- Capability to Handle Various Sample Types
- Customized Data Analysis Services
- Rapid Service Response and Cost-Effectiveness
- Disease Biomarker Discovery
- Drug Metabolism Studies
- Nutritional Research
- Animal tissue ≥ 100 mg
- Plant tissue ≥ 200 mg
- Serum/ Plasma ≥ 200 μL
- Urine ≥ 2 mL
Fumarate is a key intermediate in the tricarboxylic acid (TCA) cycle, also known as the Krebs cycle, playing a critical role in cellular energy production and metabolism. Fumarate is a four-carbon dicarboxylic acid formed through the oxidation of succinate by succinate dehydrogenase (SDH) and subsequently converted into malate by the enzyme fumarase. This conversion process is essential for the continuation of the TCA cycle, which generates ATP and other crucial metabolic intermediates necessary for cellular function.
Beyond its role in energy production, fumarate has gained attention in recent years for its involvement in various metabolic and signaling pathways. Notably, it serves as a key molecule in redox homeostasis and has been linked to the regulation of oxidative stress. Fumarate is also a precursor for the biosynthesis of amino acids and other metabolic products, underscoring its importance in cellular metabolism. Moreover, fumarate has been implicated in several pathological conditions, particularly in cancer. Mutations in the enzyme fumarase can lead to the accumulation of fumarate, contributing to a condition known as fumarate hydratase deficiency, which is associated with hereditary leiomyomatosis and renal cell carcinoma (HLRCC). This accumulation can also lead to the formation of oncometabolites, which disrupt normal cell signaling and promote tumorigenesis. Research into fumarate metabolism and its dysregulation has expanded significantly due to its role in mitochondrial function, cancer biology, and metabolic diseases. Understanding the dynamics of fumarate levels in biological systems can provide valuable insights into various disease mechanisms and metabolic disorders.
Figure 1. The Structure of Fumarate
At MtoZ Biolabs, we offer comprehensive fumarate analysis services. Utilizing our advanced LC-MS/MS platform and experienced analytical team, we can provide accurate and reliable data for your research or product development.
Analysis Workflow
Service Advantages
Applications
Our fumarate analysis service can be applied in various research areas such as:
Sample Submission Requirements
1. Sample Types
Serum, plasma, urine, tissues, and other biological samples.
2. Sample Volume
3. Storage and Shipping
Samples should be stored at -80℃ and shipped with dry ice.
Note: Please provide details on sample collection and handling.
Deliverables
1. Experimental Procedures
2. Relevant Liquid Chromatography and Mass Spectrometry Parameters
3. Detailed Information on Fumarate
4. Raw Data
5. Custom Analysis Report
At MtoZ Biolabs, we are dedicated to providing top-quality, reliable, and affordable fumarate analysis services. For more information or to request a quote, please contact us at your convenience.
How to order?
