Hyocholic Acid Analysis Service
- Rapid Analysis Cycle and Cost-Effectiveness
- Stable, Reliable, and Highly Sensitive Results
- Comprehensive One-Stop Service for Extensive Testing Needs
- User-Friendly Operation with Wide Application Scope
- Supported by Extensive Bioanalytical Resources and Advanced Platforms
Hyocholic acid (HCA) is a trihydroxy bile acid predominantly found in pig bile, recognized for its crucial role in bile acid metabolism and interactions with gut microbiota. Structurally, HCA is distinct from human bile acids, such as cholic acid and chenodeoxycholic acid, due to the presence of an α-hydroxy group at the 6th position. In comparison to muricholic acids in rodents, HCA also differs in the positioning and configuration of its hydroxyl groups. Within the liver, HCA undergoes conjugation with taurine or glycine to form taurohyocholate or glycohyocholate, which are subsequently secreted into the bile. In the intestine, bacterial 7α-dehydroxylation converts HCA into the secondary bile acid, hyodeoxycholic acid. These distinctive features make HCA particularly significant in the study of bile acid metabolism, liver function, and gut microbiota regulation.
Figure 1. Molecular Structure of Hyocholic Acid
MtoZ Biolabs offers Hyocholic Acid Analysis Service using high performance liquid chromatography-mass spectrometry (HPLC-MS). This advanced method combines the separation capabilities of HPLC with the detection power of MS, ensuring high sensitivity and specificity in HCA detection.
Analysis Workflow
Service Advantages
Sample Submission Requirements
Make sure the sample volume is greater than 0.2 g or 0.2 mL. For detailed sample submission information, please contact our customer service.
Applications
1. Bile Acid Metabolism Research: HCA serves as a vital marker in bile acid metabolism studies, enhancing our understanding of bile acids' roles in lipid metabolism and cholesterol regulation.
2. Gut Microbiota Research: HCA plays a crucial role in uncovering its influence on gut health and disease, particularly in the context of gut microbiota imbalances and their link to metabolic disorders.
3. Drug Metabolism Research: HCA is pivotal for investigating the metabolic pathways and mechanisms of drugs within the bile acid pathway.
Deliverables
1. Experimental Procedures
2. Relevant Liquid Chromatography and Mass Spectrometry Parameters
3. Detailed Information on Hyocholic Acid
4. Raw Data
5. Custom Analysis Report
Our Hyocholic Acid Analysis Service provides high-quality data support, advancing your scientific research and applications. For any inquiries or requirements, please contact us.
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