Metabolomics Analysis
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Metabolomics is the study of all metabolites in a biological organism, including small molecule metabolites and related metabolic pathways. With the continuous development of mass spectrometry technology, metabolomics has become an important tool for disease research, drug development and biomarker discovery.Our metabolomics service uses a variety of chromatographic and mass spectrometric methods to identify and quantify metabolites in biological samples. By using our analytical platform, we can screen thou
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Sebum, one of the main components of human skin, is secreted by sebaceous glands and mainly functions to protect and moisturize the skin. However, excessive sebum or changes in its composition can lead to various skin diseases such as acne, rosacea, and seborrheic dermatitis. Therefore, studying the metabolic changes of sebum is of great importance for understanding the pathogenesis and treatment of these skin diseases. MtoZ Biolabs provides sebum metabolomics services to help you explore the relationship b
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• Skeletal Muscle Metabolomics Service
The skeletal muscle is one of the largest organs in the human body, accounting for 30%-40% of body weight and has a significant impact on the body's metabolism. It can generate force and movement, is the main site of heat production, and is also the main site of protein and amino acid metabolism in the body. The dysfunction of skeletal muscle is related to many diseases such as muscle atrophy, muscle weakness, and diabetes. Therefore, the study of skeletal muscle metabolism has important theoretical and pra
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With the rapid development of biotechnology, the exploration and research of metabolites in organisms have become important issues. Metabolites are the results of countless chemical reactions in organisms, and their associations and interactions constitute a complex metabolic network. Through comprehensive and accurate analysis of these metabolites, we can obtain a wealth of information, further reveal the physiological state of organisms and the mechanism of disease occurrence. Therefore, "Metabolomics Dat
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Metabolic Pathway Analysis" refers to obtaining a metabolite spectrum through mass spectrometry, then using bioinformatics tools to statistically analyze the data, identifying differential metabolites, determining their positions in the metabolic network based on the structure and biological functions of the metabolites, and ultimately revealing their potential metabolic pathways. The main goals of metabolic pathway analysis are:
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• Ferroptosis Metabolism Analysis Service
Ferroptosis is an iron-dependent programmed cell death pathway, distinct from traditional forms like apoptosis, necrosis, or autophagy. This process is driven by the catalytic role of iron, leading to lethal accumulations of lipid peroxides. Specifically, inhibitors such as Erastin decrease cellular glutathione levels, inactivate GPX4, and intensify lipid peroxidation, culminating in cell death. Direct GPX4 inhibition, such as with RSL3, also induces ferroptosis. This pathway intersects with numerous cellul
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• Cerebrospinal Fluid Metabolomics Service
Cerebrospinal fluid (CSF), a crucial component of the central nervous system, contains an abundance of small molecular metabolites essential for researching neurodegenerative diseases and other neurological disorders. Trace elements, particularly metal ions in CSF, significantly influence enzyme activities and the pathogenesis of various neurodegenerative conditions. Despite the challenges associated with CSF collection, its metabolic profile is relatively simple, making it ideal for comprehensive analysis.
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• L-Hydroxyproline Analysis Service
MtoZ Biolabs utilizes liquid chromatography-tandem mass spectrometry (LC-MS/MS) to conduct detailed quantitative and qualitative analyses of L-Hydroxyproline. This advanced method integrates LC's rapid separation capabilities with the high detection sensitivity of MS/MS, facilitating the precise measurement of L-Hydroxyproline in complex biological matrices.
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• 3-Methyl-L-Histidine Analysis Service
MtoZ Biolabs utilizes liquid chromatography-tandem mass spectrometry (LC-MS/MS) to conduct detailed quantitative and qualitative analyses of 3-MH. This advanced method integrates LC's rapid separation capabilities with the high detection sensitivity of MS/MS, facilitating the precise measurement of 3-MH in complex biological matrices.
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• 1-Methyl-L-Histidine Analysis Service
MtoZ Biolabs utilizes liquid chromatography-tandem mass spectrometry (LC-MS/MS) to conduct detailed quantitative and qualitative analyses of 1-Methyl-L-Histidine. This advanced method integrates LC's rapid separation capabilities with the high detection sensitivity of MS/MS, facilitating the precise measurement of 1-Methyl-L-Histidine in complex biological matrices.
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