Metabolomics Analysis

• • N6,2'-O-dimethyladenosine Analysis Service

  N6,2'-O-dimethyladenosine (m6Am) is a naturally occurring modified nucleoside found predominantly in eukaryotic messenger RNA (mRNA). Structurally, m6Am is characterized by the methylation of the nitrogen at the 6th position of adenine (N6) and an additional methyl group attached to the 2'-hydroxyl group of the ribose sugar. This dual methylation confers unique chemical properties to the nucleoside, influencing its stability and interaction with proteins involved in mRNA regulation.

• • N6,N6,2'-O-trimethyladenosine Analysis Service

  N6,N6,2'-O-trimethyladenosine (m62Am) is a unique and highly methylated nucleoside found in various RNA molecules, particularly transfer RNA (tRNA) and messenger RNA (mRNA). Structurally, m62Am features two methyl groups attached to the nitrogen atoms at the N6 position of adenine, along with an additional methyl group on the 2'-hydroxyl of the ribose sugar. This extensive methylation significantly alters the chemical properties of the nucleoside.

• • 5-formylcytidine Analysis Service

  5-formylcytidine is a modified pyrimidine nucleoside. 5-formylcytidine is not only a stable epigenetic mark but also an intermediate in active DNA demethylation. It regulates gene expression, and has been shown to play critical roles in embryonic stem cell self-renewal and differentiation. 5-formylcytidine also participates in various biological processes, including transcription regulation and DNA damage repair. Its dysregulation is associated with various diseases, including cancer.

• • 2'-O-methylcytidine Analysis Service

  2'-O-methylcytidine is a modified nucleoside found in various types of RNA, where the 2'-hydroxyl group of the ribose sugar is methylated. This modification is critical for the stability, function, and regulation of RNA molecules, particularly in tRNA, rRNA, and mRNA. Structurally, 2'-O-methylcytidine retains the basic cytidine nucleobase but incorporates a methyl group at the 2' position of the ribose, which can influence RNA folding and interaction with other biomolecules.

• • 5-carboxycytidine Analysis Service

  5-carboxycytidine is a modification of cytidine, a constituent of nucleic acids, predominantly found in eukaryotic organisms. Structurally, it is distinguished from cytidine by the presence of a carboxyl group on the fifth carbon atom, hence the name 5-carboxycytidine. 5-carboxycytidine is one of the oxidation products of 5-methylcytosine (5mC), produced via the ten-eleven translocation (TET) family of enzymes.

• • 8-hydroxyadenosine Analysis Service

  8-Hydroxyadenosine is a crucial biomarker for oxidative stress and cellular damage, derived from the oxidation of adenosine. Structurally, 8-hydroxyadenosine is an adenosine derivative where the 8th position of the purine ring has been hydroxylated, forming a highly reactive compound. This modification results from the interaction between adenosine and reactive oxygen species (ROS), which are often produced during oxidative stress conditions.

• • 5'-deoxyadenosine Analysis Service

  5'-deoxyadenosine is a naturally occurring compound. The compound is derived from adenosine by the replacement of the hydroxyl group at the 5' position by hydrogen. 5'-Deoxyadenosine is an important intermediate in the biosynthesis of deoxynucleotides, which are fundamental building blocks for DNA synthesis and repair. It is involved in the regulation of DNA replication and cell proliferation, and its levels can reflect changes in cellular metabolic states and DNA repair mechanisms.

• • 2,-O-methyladenosine Analysis Service

  2,-O-methyladenosine is a methylated derivative of the nucleoside adenosine, which is part of the nucleic acids DNA and RNA. It is found in rRNA, tRNA, and mRNA of all living organisms across the biological kingdoms - from bacteria to humans. The methylation is performed by specific enzymes called methyltransferases. Recent studies have shown that changes in the levels of 2,-O-methyladenosine are associated with a variety of pathological conditions, including cancer, neurodegeneration, and...

• • N-methyladenosine Analysis Service

  N-Methyladenosine (m6A) is the most prevalent internal modification of mammalian mRNA and is critical for the regulation of RNA metabolism. It is an abundant modification in mRNA and is found in different types of RNA, including tRNA, rRNA, and others. m6A impacts various biological processes and plays a significant role in disease progression, especially in cancer and neurological disorders.

• • Xanthurenic Acid Analysis Service

  Xanthurenic acid (XA) is a metabolic byproduct of tryptophan degradation along the kynurenine pathway, which plays an important role in various biological processes. It is known to be involved in several physiological functions, including neurotransmission and immune regulation, making it a subject of increasing interest in both basic research and clinical studies.