Metabolomics Analysis

• • 1,3-bisphosphoglyceric Acid Analysis Service

  1,3-bisphosphoglyceric acid, often abbreviated as 1,3-BPG, is a key intermediate in the glycolytic pathway and is involved in the production of ATP through substrate-level phosphorylation. Abnormal levels of 1,3-BPG have been associated with various diseases, including cancer, diabetes, and heart disease. Therefore, accurate and precise quantification of 1,3-BPG is critical for understanding its metabolic pathways and potential role in disease development.

• • Lactose and Neolactose Analysis Service

  Glycosphingolipids are ubiquitous components of the cell membrane, characterized by at least one monosaccharide linked to ceramide or sphingosine via a glycosidic bond. They play crucial roles in essential cellular processes such as cell adhesion and signal transduction, mediated through protein-protein and protein-carbohydrate interactions.

• • Glycosaminoglycan Degradation Analysis Service

  Glycosaminoglycans (GAGs) are long unbranched polysaccharides consisting of a repeating disaccharide unit. They play key roles in various biological processes, such as cell proliferation, differentiation, and migration. Therefore, any alteration in the degradation of GAGs can lead to severe health complications. At MtoZ Biolabs, we provide a state-of-the-art Glycosaminoglycan Degradation Analysis Service to assist researchers in their studies of GAGs and related conditions.

• • Keratan Sulfate Analysis Service

  Keratan sulfate (KS) is a glycosaminoglycan characterized by its repeating disaccharide units of galactose and N-acetylglucosamine, which are often sulfated. It is primarily found in various connective tissues, including cartilage, cornea, and the nervous system. KS plays a pivotal role in modulating cellular functions and maintaining extracellular matrix structure due to its capacity to bind with proteins such as growth factors, cytokines, and adhesion molecules.

• • Heparan Sulfate/Heparin Analysis Service

  Heparan sulfate (HS) and heparin are complex polysaccharides, primarily function as anticoagulants, pivotal in the prevention and treatment of thrombotic disorders. Heparin acts by enhancing the activity of antithrombin III, thereby inhibiting thrombin and factor Xa, crucial enzymes in the blood coagulation cascade. This inhibition is vital for preventing the formation of clots in blood vessels, which can lead to conditions such as deep vein thrombosis and pulmonary embolism.

• • Chondroitin Sulfate and Dermatan Sulfate Analysis Service

  Chondroitin sulfate and dermatan sulfate are key components of the extracellular matrix, playing vital roles in various biological processes such as cell signaling, cell adhesion, and cell migration. Accurate quantification and analysis of these two sulfates are critical for understanding their roles in health and disease states. At MtoZ Biolabs, we offer a comprehensive Chondroitin Sulfate and Dermatan Sulfate Analysis Service utilizing advanced mass spectrometry technology.

• • Mucin Type of O-glycan Analysis Service

  Protein glycosylation, a critical post-translational modification, plays an essential role in understanding the varied functions of proteins across physiological and pathological processes. Glycosylation of cell membrane and secreted proteins primarily involves O-type and N-type glycosylation. The biological functions of Mucin-type O-glycans glycosylation, in particular, remain incompletely understood.

• • Mannose Type of O-glycan Analysis Service

  Mannose-type O-glycans represent a subset of glycosylation patterns characterized by the addition of mannose residues to serine or threonine amino acids in proteins. This type of glycosylation is less common compared to the extensively studied mucin-type O-glycans but is critical for the proper folding, stability, and function of certain glycoproteins.

• • N-glycan Analysis Service

  N-glycosylation is a key post-translational modification process that involves the attachment of glycans to the nitrogen atoms of proteins. This biological process plays a significant role in protein folding, cell-cell interactions, and immune responses. N-glycans refer to the carbohydrate chains that are covalently attached to proteins via N-glycosylation. These glycan chains, composed of various monosaccharides such as mannose, galactose, fucose, and sialic acid, exhibit significant structural diversity.

• • Glycan Biosynthesis and Metabolism Analysis

  Glycans, also known as carbohydrates or sugars, play a vital role in numerous biological processes. These include protein folding, cellular recognition, immune response, and disease pathogenesis. The biosynthesis and metabolism of glycans are complex processes, hence necessitating specialized scientific research and analysis. At MtoZ Biolabs, we offer top-tier Glycan Biosynthesis and Metabolism Analysis services using cutting-edge technology and methodologies.