N,N-Dimethylglycine Analysis Service

N,N-Dimethylglycine (DMG) is an amino acid derivative synthesized from glycine through methylation reactions. DMG synthesis primarily occurs via the one-carbon metabolism pathway. DMG plays a role in various metabolic processes, including energy metabolism, immune regulation, and neurotransmission. The metabolic products of DMG regulate cellular redox states, enhance immune functions, and are crucial in the synthesis of certain neurotransmitters.

Given DMG's key role in metabolic processes, measuring its levels is essential for understanding its metabolic pathways and functions. Variations in DMG levels may be associated with various diseases, such as metabolic disorders, immune deficiencies, and neurodegenerative diseases. Therefore, accurately analyzing DMG content is crucial for gaining insights into its metabolic mechanisms, aiding in disease diagnosis, and assessing nutritional status.

 

 

Figure 1. Molecular Structure of N,N-Dimethylglycine

 

MtoZ Biolabs offers N,N-Dimethylglycine Analysis Service using liquid chromatography-tandem mass spectrometry (LC-MS/MS). This advanced method integrates LC's rapid separation capabilities with the high detection sensitivity of MS/MS, facilitating the precise measurement of DMG in complex biological matrices.

 

Analysis Workflow

 



 

Experimental Instruments

• Liquid Chromatography-Mass Spectrometry (LC-MS)
• Gas Chromatography-Mass Spectrometry (GC-MS)
• Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

 

Service Advantages

1. High Sensitivity and Precision

HPLC-MS/MS provides highly sensitive and accurate measurements, suitable for detecting low concentrations of DMG.

 

2. Rapid and Efficient

Optimized sample preparation and fast analysis ensure quick and efficient processing.

 

3. Wide Applicability

Suitable for various biological samples, including blood, urine, and tissues.

 

4. Accurate and Reliable Data

Ensures high reproducibility and low error rates, supporting both research and clinical applications, providing reliable and specific results.

 

Sample Submission Requirements

Please ensure that the sample volume is greater than 0.2 g or 0.2 mL.

 

Deliverables

1. Experimental Procedures

2. Relevant Liquid Chromatography and Mass Spectrometry Parameters

3. Detailed Information on DMG

4. Raw Data

5. Custom Analysis Report