N-Terminal Sequence Analysis of Platelet Proteins by MS

Platelets, also known as thrombocytes, are crucial components of human blood, playing a key role in coagulation and hemostasis and participating in inflammatory responses, immune regulation, and the formation and development of tumors. The protein composition of platelets and its changes are essential for understanding these biological processes. MtoZ Biolabs uses N-terminal sequence analysis technology of proteomics to provide precise platelet proteome analysis services, revealing protein structures, functions, and dynamic changes.

 

MtoZ Biolabs' N-terminal sequence analysis technology specifically conducts qualitative and quantitative analyses of protein N-termini, accurately identifying the starting point of platelet proteins, revealing protein cleavage, modification, and mutation conditions. This technology has significant applications in platelet function research, disease diagnosis, and the development of therapeutic drugs.

 

N-Terminal Sequencing Technology Based on Edman Degradation

Edman degradation is one of the mature methods in protein N-terminal sequence analysis with wide application. MtoZ Biolabs uses Shimadzu's Edman sequencing system to provide researchers and clients with platelet protein N-terminal sequencing services. With our sequencing system, we can determine the sequence information of the first 30 amino acids at the N-terminus. With a specific protein sample system, we can determine 60-70 amino acids at the N-terminus.

 

N-Terminal Sequencing Technology Based on Mass Spectrometry

MtoZ Biolabs has developed a protein N-terminal sequence sequencing technology based on existing mass spectrometry platforms. Mass spectrometry-based N-terminal sequencing technology can realize sequence determination of N-terminal closed and PEGylated proteins, complementing Edman sequencing.

 

Application

1. Study of Thrombus Formation and Dissolution Mechanisms

By analyzing the N-terminal sequence of platelet proteins, we can gain a deeper understanding of the processes of thrombus formation and dissolution.

 

2. Discovery of Tumor Biomarkers

Changes in platelet proteins are closely related to the occurrence and development of various tumors. N-terminal sequence analysis reveals potential biomarkers.

 

3. Research of Cardiovascular Diseases

Exploring the role of platelet proteins in cardiovascular diseases provides important clues for new drug research and development.

 

4. Regulation of Inflammation and Immune Response

Analyzing changes in platelet proteins during inflammation and immune processes aids in discovering new treatment targets.

 

Service Advantages

1. High-Precision Instruments

MtoZ Biolabs uses advanced liquid chromatography-mass spectrometry technology to ensure the accuracy and sensitivity of the analysis.

 

2. Rich Experience

The MtoZ Biolabs team has a deep proteomics background and rich experimental experience, able to provide clients with professional analysis services.

 

3. Customized Solutions

Depending on the specific needs of the client, we provide customized analysis solutions to ensure satisfaction for different research purposes.

 

MtoZ Biolabs promises to provide each client with fast, accurate, and efficient services. We warmly welcome scholars and researchers worldwide to cooperate with us to jointly explore the mysteries of platelet proteomics N-terminal sequence analysis technology. Contact MtoZ Biolabs immediately for more details about platelet proteomics N-terminal sequence analysis technology!