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    Neurological Diseases Metabolomics Service

      Neurological diseases, mainly including Alzheimer's disease, Parkinson's disease, epilepsy, multiple sclerosis, etc., are one of the important aspects of global public health problems. These diseases have complex pathophysiological processes, including neurotransmitter imbalance, oxidative stress, mitochondrial dysfunction, etc. However, the exact pathogenesis of these diseases is still not fully understood, thus finding new therapeutic strategies and early detection biomarkers has become the focus of neurological disease research.

       

      Neurological Diseases Metabolomics Service1.jpg

      Plaatjie, O. N. et al. Front. Neurol. 2024.

      Figure1. LC-MS Metabolomics Analysis of Cerebrospinal Fluid

       

      Services at MtoZ Biolabs

      MtoZ Biolabs provides metabolomics solutions for neurological diseases, helping customers to explore the pathogenesis, discover biomarkers, research drug efficacy and toxicity. Our services include:

       

      1. Research on Neurotransmitter Imbalance

      ● Neurotransmitter concentration determination

      ● Study of neurotransmitter-related metabolic pathways

       

      2. Oxidative Stress Research

      ● Discovery of oxidative stress biomarkers

      ● Antioxidant mechanism research

       

      3. Mitochondrial Function Research

      ● Assessment of mitochondrial function

      ● Discovery of biomarkers for mitochondrial diseases

       

      Experimental Instruments

      We have a top-notch metabolomics analysis platform, including GC-MS, LC-MS, UPLC-MS, etc., which can screen thousands of metabolites from a single biological sample, providing a comprehensive solution for the mechanism exploration of neurological diseases.

       

      1. Chromatography

      • GC (Q Exactive) (- mode MS)
      • HPLC: HILIC (+/- mode MS)
      • HPLC: RP C18 (+/- mode MS)
      • IC (- mode MS)

       

      2. Mass Spectrometry

      • Q Exactive MS
      • Orbitrap Tribrid Mass Spectrometer
       

      Sample Submission Requirements

      We accept various types of samples such as blood, urine, cerebrospinal fluid, and tissues. Samples should be collected and stored under appropriate conditions to ensure their quality.

       

      MtoZ Biolabs is a mature partner in biopharmaceutical research, with extensive experience in the analysis of metabolomics in neurological diseases. We are committed to providing the best quality service to accelerate your research progress. If you want to know more information, please contact us. We look forward to having the opportunity to work with you.

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