Nα-Acetyl-L-Arginine Analysis Service

Nα-Acetyl-L-Arginine (Nα-Ac-L-Arg) is an acetylated derivative of L-arginine, playing significant roles in various biological processes. As a non-essential amino acid, L-arginine participates in protein synthesis, ammonia excretion, and nitric oxide production. Compared to its parent molecule, L-arginine, Nα-Ac-L-Arg exhibits unique metabolic characteristics and biological functions. For example, Nα-Ac-L-Arg has more specific roles in cell signaling, gene expression regulation, and cell proliferation and differentiation. Additionally, Nα-acetylation can enhance the stability and bioavailability of the molecule, affecting its distribution and metabolic pathways in the body. Given its diverse roles in both physiological and pathological states, precise analysis of Nα-Ac-L-Arg concentration is crucial for understanding its functions and metabolic pathways in the body.

 

 

Figure 1. Molecular Structure of Nα-Ac-L-Arg

 

MtoZ Biolabs utilizes liquid chromatography-tandem mass spectrometry (LC-MS/MS) to conduct detailed quantitative and qualitative analyses of Nα-Ac-L-Arg. This advanced method integrates LC's rapid separation capabilities with the high detection sensitivity of MS/MS, facilitating the precise measurement of Nα-Ac-L-Arg in complex biological matrices.

 

Analysis Workflow

 

 

 

Experimental Instruments

• Liquid Chromatography-Mass Spectrometry (LC-MS)
• Gas Chromatography-Mass Spectrometry (GC-MS)
• Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

 

Service Advantages

 

 

 

Sample Submission Requirements

Sample Types

Serum, plasma, urine, tissue homogenates, and other biological samples.

 

Sample Volume

At least 200 μL of liquid sample or 200 mg of tissue sample.

 

Sample Preservation

Store and transport samples at -80°C to maintain Nα-Ac-L-Arg stability.

 

Applications

Clinical Research: Monitor Nα-Ac-L-Arg levels to study its roles in metabolic diseases, cardiovascular health, and immune function.

 

Disease Monitoring: Analyze Nα-Ac-L-Arg and its metabolites to monitor pathological progress related to liver diseases, metabolic disorders, and oxidative stress.

 

Nutritional Research: Evaluate the Nα-Ac-L-Arg content in foods and supplements to guide nutritional intake and health management.

 

Drug Development: Explore the potential applications of Nα-Ac-L-Arg and its metabolites in new drug development, assessing drug efficacy and safety.

 

Deliverables

1. Experimental Procedures

2. Relevant Liquid Chromatography and Mass Spectrometry Parameters

3. Detailed Information on Nα-Ac-L-Arg

4. Raw Data

5. Custom Analysis Report

 

MtoZ Biolabs is dedicated to advancing your research and clinical projects by providing detailed insights into Nα-Ac-L-Arg's extensive physiological roles through top-tier analytical techniques and expert services.