Palmitoylation Proteomics
Palmitoylation is a critical post-translational modification in which a palmitoyl group (a 16-carbon fatty acid) is covalently attached to specific amino acid residues, such as cysteine, within proteins.
Palmitoylation
The primary function of palmitoylation is to enhance protein hydrophobicity, thereby promoting membrane association. This modification is essential for the correct localization and function of various proteins, including signaling proteins, membrane receptors, and cytoskeletal components. Additionally, palmitoylation regulates protein stability, degradation, protein-protein interactions, and intracellular signaling pathways.
Palmitoylation Proteomics
Palmitoylation proteomics is an advanced research approach aimed at identifying palmitoylated proteins and mapping their modification sites. This technique typically employs metabolic labeling (e.g., palmitic acid analogs) combined with mass spectrometry to detect and analyze palmitoylated proteins. Through this approach, numerous palmitoylated proteins and their specific modification sites have been identified. Palmitoylation is critical for the functionality of many proteins, and palmitoylation proteomics serves as a powerful tool for investigating its role in cellular processes, contributing to a deeper understanding of its significance in both health and disease.
MtoZ Biolabs, an integrated chromatography and mass spectrometry (MS) services provider.
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