Protein Asymmetric Dimethylation Analysis

Protein asymmetric dimethylation is a critical post-translational modification (PTM) that plays a significant role in regulating cellular processes such as signal transduction, gene expression, chromatin remodeling, and protein-protein interactions. This modification predominantly occurs on arginine residues and is catalyzed by protein arginine methyltransferases (PRMTs), which transfer two methyl groups to one nitrogen atom of the arginine, resulting in the formation of asymmetric dimethylarginine. Aberrant asymmetric dimethylation has been linked to various diseases, including cancer, autoimmune disorders, and neurological conditions, making precise analysis and quantification of this modification essential in life sciences research. 

 




Figure 1. Arginine Asymmetric Dimethylation

 

As a leading service provider in proteomics and PTMs, MtoZ Biolabs offers comprehensive Protein Asymmetric Dimethylation Analysis services. Our state-of-the-art platform integrates high-performance liquid chromatography (HPLC) with high-resolution mass spectrometry to deliver highly accurate and high-throughput data, supplemented by advanced bioinformatics solutions to help researchers decipher complex PTM networks.

 

Analysis Workflow

 

 

Services at MtoZ Biolabs

1. Targeted Protein Asymmetric Dimethylation Analysis

MtoZ Biolabs specializes in detecting and quantifying asymmetric dimethylation on specific proteins. Asymmetric dimethylation, primarily occurring on arginine residues, plays a pivotal role in processes such as gene regulation, protein interactions, and signal transduction. By combining immunoprecipitation for protein enrichment with high-resolution mass spectrometry, we can precisely identify dimethylation sites on target proteins, providing critical insights into protein function and regulatory mechanisms.

 

2. Asymmetric Dimethylation Proteomics

Our asymmetric dimethylation proteomics service offers a comprehensive analysis of dimethylation modifications across the entire proteome. Utilizing high-throughput mass spectrometry, we systematically profile dimethylation patterns on a global scale, offering a broad understanding of protein modifications in regulating complex biological processes. This global analysis is particularly useful for uncovering the roles of dimethylation in cellular biology and disease mechanisms, facilitating the discovery of potential biomarkers and regulatory pathways.

 

Service Advantages

Why Choose MtoZ Biolabs?

1. Advance Analysis Platform: MtoZ Biolabs established an advanced protein PTM analysis platform, guaranteeing reliable, fast, and highly accurate analysis service.

2. One-Time-Charge: Our pricing is transparent, no hidden fees or additional costs.

3. High-Data-Quality: Deep data coverage with strict data quality control. AI-powered bioinformatics platform integrate PTM proteomics analysis data providing clients with a comprehensive data report.

4. Wide Applicability: Suitable for various biological samples, including blood, urine, and tissues.

5. Customized Service: Tailored to the specific research needs of our clients, we offer flexible experimental design and personalized data analysis to ensure the achievement of research goals to the fullest extent.

 

Sample Submission Requirements

 

 

For more sample details, please consult our technical team.

 

Applications

• Disease mechanism research
• Drug target identification
• Epigenetic studies
• Signal transduction pathway analysis

 

Deliverables

What Could be Included in the Report?

1. Comprehensive Experimental Details

2. Materials, Instruments, and Methods

3. Total Ion Chromatogram & Quality Control Assessment (project-dependent)

4. Data Analysis, Preprocessing, and Estimation (project-dependent)

5. Bioinformatics Analysis

6. Raw Data Files

 

With our advanced mass spectrometry platform and expertise, MtoZ Biolabs specializes in Protein Asymmetric Dimethylation Analysis, provides accurate detection and quantification of this key modification. Additionally, we offer services for other methylation types, including monomethylation, symmetric dimethylation, trimethylation, as well as other PTMs such as propionylation, acetylation, and phosphorylation. Our goal is to provide comprehensive technical support to drive your research forward. Free project evaluation, welcome to learn more details!