Protein Glutarylation Analysis
- In-depth exploration of disease mechanisms, particularly in cancer, metabolic disorders, and neurodegenerative diseases.
- Identification and validation of novel drug targets.
- Investigations into gene expression regulation and chromatin structure alterations.
- Studies focused on metabolic pathways and their regulation.
- Systematic discovery of potential biomarkers related to glutarylation patterns.
Protein glutarylation is a significant form of lysine acylation and represents a novel category of post-translational modifications (PTMs). This modification occurs when a glutaryl group is covalently attached to lysine residues on proteins via the enzyme glutaryl transferase, resulting in a five-carbon chain structure. Glutarylation is pivotal in regulating key biological processes, including gene expression, cellular metabolism, chromatin remodeling, protein interactions, and cell signaling pathways. Emerging research highlights the strong connection between protein glutarylation and the pathogenesis of several diseases, such as cancer, metabolic disorders, and neurodegenerative diseases. Therefore, quantitative and functional studies on protein glutarylation are crucial for unraveling the mechanisms behind these pathological processes.
Tan, M. J. et al. Cell Metab. 2014.
Figure 1. Lysine Deglutarylation and Glutaryl-CoA Pathways
MtoZ Biolabs, as an expert provider in proteomics and PTM analysis, offers high-sensitivity and high-specificity glutarylation analysis services utilizing advanced mass spectrometry (LC-MS/MS) platforms. Our meticulously designed workflows enable researchers to deeply explore the functional and regulatory roles of glutarylation in diverse biological contexts, thereby advancing studies in disease mechanisms and drug development.
Analysis Workflow
Services at MtoZ Biolabs
1. Targeted Protein Glutarylation Analysis
MtoZ Biolabs provides targeted glutarylation analysis using immunoenrichment techniques paired with high-resolution mass spectrometry. By integrating labeling techniques such as TMT and iTRAQ, we ensure precise detection and quantification of glutarylation modifications on specific proteins. These methods significantly enhance detection sensitivity and quantitative precision, making them ideal for detailed functional studies of targeted proteins.
2. Glutarylation Proteomics
Our proteomic glutarylation analysis service employs a label-free, high-throughput mass spectrometry platform to analyze glutarylation modifications across the entire proteome, uncovering global modification patterns. The label-free approach offers flexible and accurate quantification across different experimental conditions, making it particularly suited for large-scale proteomic studies.
Service Advantages
Why Choose MtoZ Biolabs?
1. Advance Analysis Platform: MtoZ Biolabs established an advanced protein PTM analysis platform, guaranteeing reliable, fast, and highly accurate analysis service.
2. One-Time-Charge: Our pricing is transparent, no hidden fees or additional costs.
3. High-Data-Quality: Deep data coverage with strict data quality control. AI-powered bioinformatics platform integrate PTM proteomics analysis data providing clients with a comprehensive data report.
4. Multi-Sample Compatibility: Our platform supports a wide variety of biological samples, including cells, tissues, blood, and bodily fluids, providing flexibility to accommodate diverse research demands.
5. Customized Service: Tailored to the specific research needs of our clients, we offer flexible experimental design and personalized data analysis to ensure the achievement of research goals to the fullest extent.
Sample Submission Requirements
For more sample details, please consult our technical team.
Applications
Deliverables
What Could be Included in the Report?
1. Comprehensive Experimental Details
2. Materials, Instruments, and Methods
3. Total Ion Chromatogram & Quality Control Assessment (project-dependent)
4. Data Analysis, Preprocessing, and Estimation (project-dependent)
5. Bioinformatics Analysis
6. Raw Data Files
At MtoZ Biolabs, we are dedicated to delivering high-quality, accurate protein PTM analysis services. Leveraging our state-of-the-art technology platforms and extensive expertise, we provide comprehensive data support to foster scientific innovation and breakthroughs. For further information, please contact us.
How to order?
