Protein Lysine Methylation Analysis

Protein lysine methylation is a crucial post-translational modification (PTM) catalyzed by lysine methyltransferases (KMTs), which add one or more methyl groups to lysine residues on proteins. This modification exists in three forms: monomethylation (Kme1), dimethylation (Kme2), and trimethylation (Kme3). Lysine methylation plays a vital role in regulating chromatin structure, gene expression, signal transduction, and the cell cycle. Aberrations in lysine methylation are associated with various diseases, including cancer, neurodegenerative disorders, and metabolic imbalances.

 

 

Figure 1. Lysine Methylation

 

MtoZ Biolabs utilizes advanced liquid chromatography-mass spectrometry (LC-MS/MS) platforms to offer highly sensitive and precise lysine methylation analysis. Our skilled team and state-of-the-art technology empower researchers to explore the biological significance and underlying mechanisms of lysine methylation in various cellular processes..

 

Analysis Workflow

 



 

Services at MtoZ Biolabs

1. Targeted Protein Lysine Methylation Analysis

MtoZ Biolabs specializes in target protein lysine methylation analysis, utilizing immunoprecipitation to enrich specific proteins and mass spectrometry for the precise identification of lysine methylation sites. This service is ideal for investigating the role of lysine methylation in gene regulation, cell differentiation, and oncogenesis.

 

2. Lysine Methylation Proteomics

Our lysine methylation proteomics service provides comprehensive profiling of lysine methylation across the entire proteome. Using high-throughput mass spectrometry, we systematically analyze methylation patterns, making it an invaluable tool for research in cancer, neuroscience, and metabolism, and aiding in the discovery of biomarkers and regulatory pathways.

 

Service Advantages

Why Choose MtoZ Biolabs?

1. Advance Analysis Platform: MtoZ Biolabs established an advanced protein PTM analysis platform, guaranteeing reliable, fast, and highly accurate analysis service.

2. One-Time-Charge: Our pricing is transparent, no hidden fees or additional costs.

3. High-Data-Quality: Deep data coverage with strict data quality control. AI-powered bioinformatics platform integrate PTM proteomics analysis data providing clients with a comprehensive data report.

4. Multi-Sample Compatibility: Our platform supports a wide variety of biological samples, including cells, tissues, blood, and bodily fluids, providing flexibility to accommodate diverse research demands.

5. Customized Service: Tailored to the specific research needs of our clients, we offer flexible experimental design and personalized data analysis to ensure the achievement of research goals to the fullest extent.

 

Sample Submission Requirements

 



For more sample details, please consult our technical team.

 

Applications

• Investigating disease mechanisms
• Screening and validating drug targets
• Discovering biomarkers
• Conducting epigenetic studies
• Analyzing signal transduction pathways

 

Deliverables

What Could be Included in the Report?

1. Comprehensive Experimental Details

2. Materials, Instruments, and Methods

3. Total Ion Chromatogram & Quality Control Assessment (project-dependent)

4. Data Analysis, Preprocessing, and Estimation (project-dependent)

5. Bioinformatics Analysis

6. Raw Data Files

 

MtoZ Biolabs is dedicated to providing researchers with high-quality, reliable protein PTM analysis services. Our Lysine Methylation Analysis, powered by cutting-edge technology and deep expertise, offers the critical data needed to advance your research. Contact us today to discuss how we can support your scientific goals.