Resources

Proteomics Databases



Metabolomics Databases

• • Workflow of Quantitative Acetylproteomics

  Acetylation, a significant post-translational modification (PTM), plays a key role in cellular processes such as signal transduction, gene regulation, and metabolism. Quantitative acetylproteomics allows for large-scale analysis of protein acetylation, uncovering its dynamic changes under various biological conditions, thus helping researchers better understand the functional roles of acetylation.

• • Principle of Quantitative Acetylproteomics

  Post-translational modifications (PTMs) play a crucial role in regulating cellular functions. Among them, acetylation is one of the most common, impacting protein structure, function, and interactions with other molecules. Quantitative acetyl proteomics involves the high-throughput analysis of acetylated proteins and their changes under various physiological conditions, shedding light on their biological functions.

• • Mechanism of Quantitative Methylomics

  Methylomics focuses on studying the methylation states of biological macromolecules like DNA and proteins, and understanding their functional impacts. In genomic and epigenomic research, the modification of 5-methylcytosine (5mC) in DNA has been extensively studied. This modification plays a critical role in gene expression regulation, genomic stability, and cellular differentiation.

• • Application of Quantitative Methylomics

  Methylation is a common epigenetic modification that occurs at both the DNA and protein levels, influencing gene expression regulation, cell differentiation, development, and various other biological processes. Quantitative methylomics, utilizing high-throughput techniques, enables precise quantitative analysis of the levels and distribution patterns of DNA or protein methylation, allowing researchers to better understand epigenetic regulatory mechanisms.

• • Workflow of Quantitative Methylomics

  Methylation is one of the most common epigenetic modifications, impacting both DNA and proteins. It plays a pivotal role in the regulation of gene expression and cellular function. In genomic studies, DNA methylation changes are frequently associated with disease mechanisms, especially cancer development.

• • Principle of Quantitative Methylomics

  Methylation is a critical component of epigenetic regulation, influencing gene expression by modifying both DNA and histones. As high-throughput technologies advance, quantitative methylomics has emerged as a powerful tool for examining genome-wide methylation patterns, particularly in the context of cancer, developmental biology, and complex diseases.

• • Mechanism of Quantitative Acetylomics

  Acetylation is a crucial post-translational modification (PTM) that plays a key role in various biological processes by regulating protein activity, function, and interactions. Quantitative acetylomics aims to systematically analyze the dynamic changes of protein acetylation and reveal their functional roles in physiological and pathological conditions.

• • Application of Quantitative Acetylomics

  Acetylation is an essential post-translational modification that regulates numerous biological processes. By acetylating lysine residues on proteins, processes like cell signaling, gene expression, and metabolic regulation can be modulated. Quantitative acetylomics, a high-throughput approach, provides a systematic analysis of acetylated proteomes and their alterations under various physiological conditions.

• • Workflow of Quantitative Acetylomics

  Acetylomics is a systematic approach used to study protein acetylation modifications, widely applied to uncover protein functions, regulatory mechanisms, and their association with diseases. Quantitative acetylomics specifically focuses on the quantitative changes in protein acetylation and utilizes advanced mass spectrometry (MS) and bioinformatics to analyze the dynamic acetylation states of proteins.

• • Principle of Quantitative Acetylomics

  Acetylation is a common post-translational modification (PTM) that influences protein function, structure, and interaction by adding acetyl groups to specific sites. Dynamic changes in acetylation play a pivotal role in key cellular processes, such as gene expression, cell cycle regulation, and metabolic control.