Taurolithocholic Acid-3-Sulfate Analysis Service

Taurolithocholic acid-3-sulfate (TLCA-3S) is a sulfated derivative of taurolithocholic acid, predominantly found in mammalian bile. TLCA-3S is generated through the sulfation of taurolithocholic acid, a biochemical modification that enhances its water solubility, thereby promoting its excretion from the body. As a bile acid conjugate, TLCA-3S plays a pivotal role in the enterohepatic circulation of bile acids, contributing significantly to bile acid detoxification and homeostasis. It also offers cellular protection against the cytotoxic effects of hydrophobic bile acids. TLCA-3S is involved in various physiological processes, including bile acid signaling and lipid metabolism, and its dysregulation has been closely associated with liver and bile-related diseases, such as cholestasis and gallstone formation. Given the importance of TLCA-3S in these critical metabolic pathways, its precise quantification and analysis are vital for advancing our understanding of bile acid metabolism, liver function, and the assessment of drug-induced liver injury. The detection and analysis of TLCA-3S offer valuable insights into its role in maintaining bile acid balance and its potential as a biomarker for liver and gallbladder disorders.

 

Figure 1. Molecular Structure of Taurolithocholic Acid-3-Sulfate

 

MtoZ Biolabs offers Taurolithocholic Acid-3-Sulfate Analysis Service using high performance liquid chromatography-mass spectrometry (HPLC-MS). This advanced method combines the separation capabilities of HPLC with the detection power of MS, ensuring high sensitivity and specificity in TLCA-3S detection.

 

Analysis Workflow

 



 

Service Advantages

1. High Sensitivity and Precision

HPLC-MS/MS provides highly sensitive and accurate measurements, suitable for detecting low concentrations of TLCA-3S.

 

2. Rapid and Efficient

Optimized sample preparation and fast analysis ensure quick and efficient processing.

 

3. Wide Applicability

Suitable for various biological samples, including blood, urine, feces, and tissues.

 

4. Accurate and Reliable Data

Ensures high reproducibility and low error rates, supporting both research and clinical applications, providing reliable and specific results.

 

Sample Submission Requirements

Make sure the sample volume is greater than 0.2 g or 0.2 mL. For detailed sample submission information, please contact our customer service.

 

Deliverables

1. Experimental Procedures

2. Relevant Liquid Chromatography and Mass Spectrometry Parameters

3. Detailed Information on Taurolithocholic Acid-3-Sulfate

4. Raw Data

5. Custom Analysis Report

 

Our Taurolithocholic Acid-3-Sulfate Analysis Service provides high-quality data support, advancing your scientific research and applications. For any inquiries or requirements, please contact us.