Taurolithocholic Acid Analysis Service

Taurolithocholic acid (TLCA) is a secondary bile acid formed by the conjugation of lithocholic acid (LCA) with taurine, making it an important component of bile. TLCA is primarily produced when intestinal microorganisms convert primary bile acids into lithocholic acid, which then conjugates with taurine. TLCA plays a crucial role in the emulsification and absorption of dietary fats and is key in cholesterol metabolism and maintaining liver health. Abnormal levels of TLCA, particularly when excessively accumulated, are associated with various hepatobiliary diseases, including cholestasis, cirrhosis, and gallstones. Additionally, TLCA has been widely studied for its toxic effects, as it may exhibit cytotoxicity to various cell types. Therefore, accurate analysis of TLCA and its metabolites is critical for diagnosing, researching, and treating liver and bile duct diseases.

 

Figure 1. Molecular Structure of Taurolithocholic Acid

 

MtoZ Biolabs offers Taurolithocholic Acid Analysis Service using high performance liquid chromatography-mass spectrometry (HPLC-MS). This advanced method combines the separation capabilities of HPLC with the detection power of MS, ensuring high sensitivity and specificity in TLCA detection.

 

Analysis Workflow

 



 

Service Advantages

1. High Sensitivity and Precision

HPLC-MS/MS provides highly sensitive and accurate measurements, suitable for detecting low concentrations of TLCA.

 

2. Rapid and Efficient

Optimized sample preparation and fast analysis ensure quick and efficient processing.

 

3. Wide Applicability

Suitable for various biological samples, including blood, urine, feces, and tissues.

 

4. Accurate and Reliable Data

Ensures high reproducibility and low error rates, supporting both research and clinical applications, providing reliable and specific results.

 

Sample Submission Requirements

Make sure the sample volume is greater than 0.2 g or 0.2 mL. For detailed sample submission information, please contact our customer service.

 

Deliverables

1. Experimental Procedures

2. Relevant Liquid Chromatography and Mass Spectrometry Parameters

3. Detailed Information on Taurolithocholic Acid

4. Raw Data

5. Custom Analysis Report

 

MtoZ Biolabs is dedicated to advancing your research and clinical projects by providing detailed insights into TLCA's extensive physiological roles through top-tier analytical techniques and expert services.