TMAO Quantitative Analysis Service
- Advanced UPLC-MS equipment with high sensitivity and accuracy
- Comprehensive data analysis supported by a team of experienced analysts
- Strict quality control to ensure reliable results
- Personalized service to meet various research needs
- Disease Diagnosis: TMAO level can be used as a biomarker for cardiovascular diseases and other metabolic disorders.
- Drug Metabolism Studies: TMAO quantification can provide insights into the metabolism of choline and carnitine-containing drugs.
- Nutritional Research: TMAO level can indicate the diet pattern and gut microbiota activity.
- Sample Type: Serum, plasma, urine, tissue, cells, etc.
- Sample Volume/Weight: At least 200 μL for liquid samples, 100 mg for solid samples, or 1 x 10⁷ cells.
- Storage and Shipping: Samples should be stored at -80°C and shipped with dry ice.
Trimethylamine N-oxide (TMAO) is formed by the oxidation of trimethylamine (TMA), which is produced by gut microbiota metabolism and further oxidized in the liver by flavin monooxygenases (FMOs). Precursors of TMAO include carnitine, betaine, and creatinine, primarily derived from foods such as red meat, poultry, eggs, and dairy products.
As research on gut microbiota progresses, scientists have identified strong associations between elevated levels of TMAO and related metabolites with a variety of diseases, including cardiovascular disease, myocardial infarction, stroke, diabetes, chronic kidney disease, and cancer. Targeted quantitative analysis of TMAO and its metabolites offers valuable insights for disease diagnosis, prediction, etiological research, and therapeutic efficacy assessment.
Chen, S. et al. Cell Metab. 2019.
Figure 1. Mechanism of TMAO-Induced Metabolic Dysfunction
At MtoZ Biolabs, we offer TMAO Quantitative Analysis Service based on UPLC-MS technique to provide precise quantification of TMAO using high-resolution mass spectrometry.
Analysis Workflow
Service Advantages
Applications
Sample Submission Requirements
For specific sample submission requirements, please contact our customer service team.
Deliverables
1. Experimental Procedures
2. Relevant Liquid Chromatography and Mass Spectrometry Parameters
3. Detailed Information on TMAO Quantitative Analysis
4. Raw Data
5. Custom Analysis Report
Contact us today to find out how our TMAO Quantitative Analysis Service can assist you in your research and diagnosis work.
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