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    Vibrio Cholerae Metabolome Analysis Service

      Vibrio cholerae is a Gram-negative bacterium responsible for cholera, a severe diarrheal disease that remains a significant public health challenge in many parts of the world. This pathogen thrives in aquatic environments and is transmitted primarily through contaminated water and food. Once ingested, V. cholerae colonizes the small intestine, producing the cholera toxin, which disrupts the normal ion transport in the intestinal epithelium, leading to rapid fluid loss and severe dehydration. The global burden of cholera, particularly in low-resource settings, underscores the need for advanced research to better understand the metabolic pathways that drive V. cholerae virulence, survival, and adaptation.

       

      By elucidating the metabolic profiles associated with different environmental conditions, stages of infection, and host interactions, metabolomics can reveal critical information on the bacterium's pathogenic mechanisms, resistance to antibiotics, and potential vulnerabilities. Moreover, understanding the metabolic networks of V. cholerae can aid in the development of novel therapeutic strategies, improve diagnostic methods, and enhance public health interventions to control and prevent cholera outbreaks.

       

      MtoZ Biolabs is committed to supporting cholera research with our advanced Vibrio Cholerae Metabolome Analysis Service. Leveraging state-of-the-art mass spectrometry technologies and expert bioinformatics, our service provides a detailed and comprehensive analysis of the metabolic alterations in V. cholerae, offering researchers crucial data to further their studies and contribute to the global fight against cholera.

       

      We implement liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS) techniques for metabolome analysis. These techniques enable the sensitive and accurate detection of metabolites, including amino acids, lipids, sugars, nucleotides, organic acids, and other small molecules. With high-resolution MS, we can analyze thousands of metabolites simultaneously, providing a comprehensive view of the metabolic status of Vibrio cholerae.

       

      Analysis Workflow

       

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      Service Advantages

      • Extensive expertise in handling various biological samples and extracting metabolites.
      • State-of-the-art mass spectrometry platforms: UPLC-MS, LC-MS, GC-MS, MRM method. 
      • Strict quality control to ensure reliable results.
      • Comprehensive statistical and bioinformatics analysis.
      • Personalized service to meet various research needs.

       

      Applications

      This service can help researchers to:

      • Understand the metabolic responses of V. cholerae under different conditions.
      • Identify potential metabolic markers associated with pathogenicity.
      • Discover novel drug targets for cholera treatment.

       

      Deliverables

      1. Experimental Procedures

      2. Relevant Mass Spectrometry Parameters

      3. Detailed Information on Vibrio Cholerae Metabolome Analysis

      4. Raw Data

      5. Custom Analysis Report

       

      For more information about our Vibrio Cholerae Metabolome Analysis Service, please contact us.

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