11-Deoxycorticosterone Analysis Service

11-Deoxycorticosterone (DOC), also referred to as 21-hydroxyprogesterone, is a steroid hormone secreted by the adrenal gland with significant mineralocorticoid activity. It functions as a precursor to aldosterone and is critical in regulating electrolyte balance and blood pressure through its sodium-retaining properties, thus playing a vital role in mineral metabolism. As a pivotal molecule in the endocrine system, DOC serves as a key biomarker for assessing adrenal function and diagnosing endocrine disorders, such as primary aldosteronism. Additionally, it is integral to the study of mineral metabolism and electrolyte balance. With advancing research into endocrine regulation mechanisms, the precise quantification of DOC is increasingly crucial for both clinical diagnostics and fundamental research.

 



Figure 1. Molecular Structure of 11-Deoxycorticosterone

 

MtoZ Biolabs offers 11-Deoxycorticosterone Analysis Service using high performance liquid chromatography-mass spectrometry (HPLC-MS). This advanced method combines the separation capabilities of HPLC with the detection power of MS, ensuring high sensitivity and specificity in DOC detection.

 

Analysis Workflow

 



 

Service Advantages

1. High Sensitivity

Detects very low concentrations of DOC accurately.

 

2. High Specificity

Differentiates DOC from other compounds using mass spectrometry.

 

3. Rapid Analysis

Efficient sample preparation and fast detection processes for high-throughput analysis.

 

4. High Accuracy

Strict quality control ensures accuracy and reproducibility.

 

5. Versatility

Capable of analyzing DOC and its related metabolites.

 

Sample Submission Requirements

Make sure the sample volume is greater than 0.2 g or 0.2 mL. For detailed sample submission information, please contact our customer service.

 

Applications

• Assists in evaluating adrenal function and diagnosing endocrine disorders such as primary aldosteronism and Cushing's syndrome.
• Provides critical data for studying disorders in mineral metabolism, aiding in the understanding of DOC's role in sodium and potassium balance.
• Facilitates the study of drug metabolism and pharmacodynamics related to DOC.
• Evaluates DOC levels in the body to inform hormone therapy and intervention strategies.

 

Deliverables

1. Experimental Procedures

2. Relevant Liquid Chromatography and Mass Spectrometry Parameters

3. Detailed Information on 11-Deoxycorticosterone

4. Raw Data

5. Custom Analysis Report

 

MtoZ Biolabs is dedicated to advancing your research and clinical projects by providing detailed insights into DOC's extensive physiological roles through top-tier analytical techniques and expert services.