4-Methoxyestrone Analysis Service
- Identifying new disease biomarkers
- Improving disease diagnosis
- Speeding up the discovery of innovative therapeutics
- Uncovering new insights into disease mechanisms
- Animal tissue ≥ 100 mg
- Plant tissue ≥ 200 mg
- Serum/ Plasma ≥ 200 μL
- Urine ≥ 2 mL
4-Methoxyestrone (chemical formula C19H24O3) is a steroidal estrogen derivative and a metabolite of estrone. Its basic structure consists of a steroid backbone composed of four carbon rings (A, B, C, D), similar to other estrogens. Compared to other estrogens, 4-methoxyestrone has weaker biological activity. While it retains some estrogenic activity, its effect is significantly lower than that of estrone and estradiol. This reduced estrogenic activity classifies it as an anti-estrogenic metabolite, potentially reducing the levels of active estrogens in the body and thereby lowering the risk of estrogen-related diseases. In particular, 4-methoxyestrone has shown inhibitory effects on estrogen-dependent tumors, such as breast cancer, in certain studies. By lowering the levels of active estrogens in the body, 4-methoxyestrone can exert protective effects. 4-Methoxyestrone is primarily metabolized in the liver, where it is further broken down into water-soluble compounds and excreted via urine or bile. Research suggests that 4-methoxyestrone and its metabolites may have antioxidant and anti-inflammatory properties, potentially reducing oxidative stress, especially in pathological conditions associated with excessive estrogen activity.
In biomedical and environmental sciences, detecting 4-methoxyestrone and its metabolites is of great importance. In humans, the level of 4-methoxyestrone can reflect an individual's estrogen metabolism status, particularly in relation to estrogen-associated diseases such as breast cancer and endometrial cancer. By analyzing changes in 4-methoxyestrone and its metabolites, researchers can better understand an individual's metabolic response to estrogen, especially during menopause and postmenopause, when estrogen fluctuations can significantly impact health. The application of highly sensitive techniques such as mass spectrometry allows for precise quantification of 4-methoxyestrone and its metabolites. This is crucial for exploring the mechanisms of estrogen metabolism disorders, developing new therapeutic approaches, and monitoring the impact of hormone pollutants in the environment.
Figure 1. The Structure of 4-Methoxyestrone
MtoZ Biolabs, an integrated chromatography and mass spectrometry (MS) services provider, providing advanced metabolomics, proteomics and biopharmaceutical analysis services to researchers in biochemistry, biotechnology, and biopharmaceutical fields. Our ultimate aim is to provide more rapid, high-throughput, and cost-effective analysis, with exceptional data quality and minimal sample consumption. MtoZ Biolabs utilizes an LC-MS-based metabolomics research platform for the analysis of 4-methoxyestrone. We ensure the accuracy of the quantification of 4-methoxyestrone and its metabolites, as well as the comprehensiveness and precision of metabolite identification. If you are interested in our 4-methoxyestrone analysis service, please feel free to contact us at any time, and we will be fully committed to providing you with high-quality analytical services and technical support.
Analysis Workflow
Service Advantages
1. Advance Analysis Platform: MtoZ Biolabs established an advanced 4-methoxyestrone analysis platform, guaranteeing reliable, fast, and highly accurate analysis service.
2. One-Time-Charge: Our pricing is transparent, no hidden fees or additional costs.
3. High-Data-Quality: Extensive data coverage with rigorous quality control. Our advanced analysis platform consolidates all 4-methoxyestrone analysis data, delivering clients a detailed and comprehensive data report.
4. Quick Turnaround: We offer a fast analysis process to ensure that clients receive high-quality data within a short time.
Applications
Sample Submission Requirements
1. Sample Types
Serum, plasma, urine, tissues and other biological samples. Each sample requires selection of more than 3 materials under the same condition.
2. Sample Volume
3. Sample Preservation
Store at -80°C to maintain stability.
Note: Provide details on sample collection and handling.
Deliverables
1. Experimental Procedures
2. Relevant Liquid Chromatography and Mass Spectrometry Parameters
3. Detailed Information on 4-Methoxyestrone
4. Raw Data
5. Custom Analysis Report
Through our 4-methoxyestrone analysis service, we aim to expedite your research and product development processes by delivering accurate and reliable results.
How to order?
