5'-Deoxy-5'-methylthioadensine Analysis Service

5'-Deoxy-5'-methylthioadenosine (MTA) is a sulfur-containing nucleoside derivative characterized by a methylthio group (–SCH₃) attached to the 5' carbon of the ribose sugar in the adenosine molecule. It is a byproduct of polyamine biosynthesis, produced through the enzymatic conversion of S-adenosylmethionine (SAM) by S-adenosylmethionine decarboxylase (SAMDC) and subsequent reactions. MTA is found in various tissues and cells where it plays important roles in cellular metabolism and signal transduction.

 

Accurate quantification of MTA is crucial for understanding its role in various biological processes, including cellular growth, apoptosis, and immune response regulation. Abnormal levels of MTA may indicate dysregulation in pathways such as polyamine metabolism or methylation reactions, which are associated with certain cancers, liver diseases, and inflammatory conditions. Measuring MTA levels can be useful in both clinical and research settings to assess the metabolic state of cells and the effectiveness of therapeutic interventions targeting these pathways. The analysis of MTA is typically performed using mass spectrometry-based techniques, such as liquid chromatography-mass spectrometry (LC-MS) or gas chromatography-mass spectrometry (GC-MS). These methods offer high sensitivity and specificity, allowing for the accurate detection of MTA in biological samples, including plasma, serum, or tissue extracts.

 



Figure 1. The Structure of 5'-Deoxy-5'-Methylthioadensine

 

MtoZ Biolabs leverages its advanced liquid chromatography-mass spectrometry (LC-MS) platform and the expertise of our metabolomics team to offer a pioneering 5'-Deoxy-5'-Methylthioadensine Analysis Service. Our service ensures a comprehensive analysis of 5'-deoxy-5'-methylthioadensine with high sensitivity and accuracy.

 

Analysis Workflow 

 



 

Service Advantages

1. Continuously refined protocols and cutting-edge analytical tools  

 

2. Expert experimental planning  

 

3. Rapid processing times  

 

4. Exceptional precision, selectivity, and sensitivity

 

Applications

• Qualitative analysis of the metabolites of 5'-deoxy-5'-methylthioadensine
• Quantitative analysis of 5'-deoxy-5'-methylthioadensine content
• Help in deciphering the pharmacology of 5'-deoxy-5'-methylthioadensine

 

Sample Submission Requirements

1. Sample Types

Serum, plasma, urine, tissues, and other biological samples. For each sample, more than 3 materials under the same condition should be selected.

 

2. Sample Volume

• Animal tissue ≥ 100 mg
• Plant tissue ≥ 200 mg
• Serum/ Plasma ≥ 200 μL
• Urine ≥ 2 mL

 

3. Sample Preservation

Store at -80°C to maintain stability.

 

Note: Provide details on sample collection and handling.

 

Deliverables

1. Experimental Procedures

2. Relevant Liquid Chromatography and Mass Spectrometry Parameters

3. Detailed Information on 5'-Deoxy-5'-Methylthioadensine

4. Raw Data

5. Custom Analysis Report

 

Our 5'-Deoxy-5'-Methylthioadensine Analysis Service is designed to support your research and product development by providing precise and reliable results. By choosing MtoZ Biolabs, you ensure the comprehensive analysis of 5'-deoxy-5'-methylthioadensine, which is crucial in understanding its pharmacological action and potential applications in therapeutics.