Ala-Phe Analysis Service
- Extensive expertise in handling various biological samples and extracting metabolites.
- State-of-the-art mass spectrometry platforms.
- Strict quality control to ensure reliable results.
- Comprehensive statistical and bioinformatics analysis.
- Personalized service to meet various research needs.
- Discovery of new disease biomarkers
- Enhancing disease diagnosis
- Accelerating the discovery of novel therapeutics
- Revealing new insights into disease mechanisms
- Animal tissue ≥ 100 mg
- Plant tissue ≥ 200 mg
- Serum/ Plasma ≥ 200 µL
- Urine ≥ 2 mL
Ala-Phe is a dipeptide composed of the amino acids alanine (Ala) and phenylalanine (Phe). Alanine is a non-polar, aliphatic amino acid with a simple methyl side chain, while phenylalanine contains an aromatic side chain with a phenyl group. The unique molecular structure formed by the peptide bond between the carboxyl group of alanine and the amino group of phenylalanine retains the hydrophobic characteristics of alanine and the aromatic properties of phenylalanine. Due to its constituent components, Ala-Phe is involved in the regulation of amino acid metabolism and energy homeostasis. Alanine plays a critical role in the alanine cycle, which is essential for gluconeogenesis and maintaining blood glucose levels. Phenylalanine is a precursor of tyrosine, which is necessary for the synthesis of several neurotransmitters, including dopamine, norepinephrine, and epinephrine.
Given its role in key metabolic pathways, Ala-Phe has the potential to serve as a biomarker for diagnosing metabolic disorders. Changes in Ala-Phe levels, whether elevated or reduced, may indicate abnormalities in amino acid metabolism, such as disorders of phenylalanine metabolism (e.g., phenylketonuria) or conditions associated with muscle wasting and malnutrition. Ala-Phe may also serve as an indicator of muscle protein degradation. During muscle breakdown, proteins are decomposed into their constituent amino acids and dipeptides, such as Ala-Phe. By analyzing Ala-Phe levels in biological fluids, such as blood or urine, it is possible to assess muscle protein breakdown and overall protein turnover in the body.
Figure 1. The Structure of Ala-Phe
At MtoZ Biolabs, we offer a state-of-the-art Ala-Phe Analysis Service, powered by our sophisticated liquid chromatography-mass spectrometry (LC-MS) platform, supported by our expert metabolomics team. Our service is designed to offer a comprehensive analysis of Ala-Phe to meet researchers' needs.
Analysis Workflow
Service Advantages
Applications
Our Ala-Phe Analysis Service can aid in:
Sample Submission Requirements
1. Sample Types
Serum, plasma, urine, tissues, and other biological samples. At least three replicates per sample type under the same condition are required.
2. Sample Volume
3. Sample Preservation
Samples should be stored at -80°C to ensure stability.
Note: Please provide detailed information on sample collection and handling.
Deliverables
1. Experimental Procedures
2. Relevant Liquid Chromatography and Mass Spectrometry Parameters
3. Detailed Information on Ala-Phe
4. Raw Data
5. Custom Analysis Report
Through our Ala-Phe analysis service, we are committed to accelerating your research and product development processes by providing precise and reliable results. Trust MtoZ Biolabs for all your metabolomics analysis needs.
How to order?
