Allopregnanolone Analysis Service
- Extensive expertise in handling various biological samples and extracting metabolites.
- State-of-the-art mass spectrometry platforms.
- Strict quality control to ensure reliable results.
- Comprehensive statistical and bioinformatics analysis.
- Personalized service to meet various research needs.
- Discovering new disease biomarkers
- Enhancing disease diagnosis
- Speeding up the discovery of innovative therapeutics
- Uncovering new insights into disease mechanisms
- Animal tissue ≥ 100 mg
- Plant tissue ≥ 200 mg
- Serum/ Plasma ≥ 200 μL
- Urine ≥ 2 mL
Allopregnanolone is a naturally occurring neurosteroid produced from progesterone through the actions of 5α-reductase and 3α-hydroxysteroid dehydrogenase. It is widely present in the central nervous system and peripheral tissues and exhibits significant biological activity. Allopregnanolone can bind to gamma-aminobutyric acid (GABA) type A receptors as a positive allosteric modulator, enhancing GABA's inhibitory neurotransmission, thereby playing a crucial role in sedation, anti-anxiety, anticonvulsant, and neuroprotective effects.
Due to its significant role in regulating nervous system functions, allopregnanolone may have potential therapeutic applications in treating neuropsychiatric disorders related to mood, anxiety, depression, and epilepsy. Monitoring the levels of allopregnanolone in the body may serve as a potential biomarker for these conditions. Measuring its concentration in plasma or cerebrospinal fluid can help with early diagnosis and monitoring of disease progression. Studying the metabolic pathways and regulatory mechanisms of allopregnanolone can provide insights into the metabolism of neurosteroids and their changes under healthy and pathological conditions, offering new strategies for the treatment of neuropsychiatric disorders.
Figure 1. The Structure of Allopregnanolone
MtoZ Biolabs offers a state-of-the-art Allopregnanolone Analysis Service, powered by our advanced liquid chromatography-mass spectrometry (LC-MS) platform and expert metabolomics team. Our service provides a comprehensive allopregnanolone analysis, ensuring high sensitivity and accuracy.
Analysis Workflow
Service Advantages
Applications
Sample Submission Requirements
1. Sample Types
Serum, plasma, urine, tissues and other biological samples. It is necessary to select more than 3 materials with the same condition for each sample.
2. Sample Volume
3. Sample Preservation
Store at -80°C to maintain stability.
Note: Provide details on sample collection and handling.
Deliverables
1. Experimental Procedures
2. Relevant Liquid Chromatography and Mass Spectrometry Parameters
3. Detailed Information on Allopregnanolone
4. Raw Data
5. Custom Analysis Report
Through our allopregnanolone analysis service, we aim to support your research and product development processes by providing accurate and trustworthy results. If you have any questions or would like to learn more about our analysis services, please feel free to contact us. We look forward to collaborating with you to advance scientific research and clinical applications.
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