Antibody de novo seq

Antibodies are specialized proteins produced by B cells in the immune system, designed to recognize and neutralize pathogens such as bacteria and viruses. They are classified into five primary types: IgG, IgA, IgM, IgE, and IgD, each playing a unique role in the immune response. These antibodies are extensively used in biomedical research, diagnostics, and therapeutic applications.

 

 

Figure 1. Structure of Different Types of Antibodies

 

De novo antibody sequencing is a method that directly determines the sequence of unknown antibodies or their fragments without needing reference sequences. This technique is essential for antibody drug development, epitope mapping, and immunological research. De novo sequencing provides high-resolution sequence data, revealing the primary structure of antibodies and helping scientists understand their characteristics and functions. This allows researchers to discover new antibodies, optimize existing antibody drugs, and explore antibody-antigen interactions, thus advancing vaccine development and disease treatment.

 

MtoZ Biolabs offers expert de novo antibody sequencing services, using advanced mass spectrometry technology and bioinformatics tools to provide precise and comprehensive antibody sequence information, significantly supporting scientific research and applications.

 

Analysis Workflow

 



 

Service Advantages

 



 

Applications

Antibody Drug Development: Discover and optimize antibody drug sequences through de novo sequencing, supplying critical data for drug development.

 

Epitope Mapping: Accurately identify antibody-binding epitope sequences, supporting vaccine development and disease research.

 

Post-Translational Modification Analysis: Uncover antibody post-translational modifications and comprehend their roles in immune responses.

 

Immunological Research: Furnish precise antibody sequence information for immunological research, aiding in-depth investigations of antibody functions and mechanisms.

 

Deliverables

1. Experimental Procedures

2. Relevant Mass Spectrometry Parameters

3. Detailed Information on Antibody Sequences

4. Mass Spectrometry Images

5. Raw Data