Antibody Drug Monosaccharide Spectrum Analysis

Antibody drugs are a significant advancement in the biopharmaceutical field in recent years, widely used in various diseases, especially in the treatment of cancer and autoimmune diseases. They mainly exert their therapeutic effects by recognizing and binding to specific antigens. This specificity makes antibody drugs have higher selectivity and reduced side effects in treatment. However, the safety, stability, and functionality of antibody drugs largely depend on their glycan structures. These glycan structures may be subject to minor changes during the production process, and these changes can affect the efficacy and safety of the drugs.

 

Monosaccharide spectrum analysis is a high-precision analytical technique for the glycan structure of antibody drugs. By conducting detailed qualitative and quantitative analysis of glycans, researchers can obtain detailed information about the glycosylation of antibody drugs. This information is critical for ensuring the consistency of the production process, optimizing production conditions, improving the stability and efficacy of drugs, and monitoring potential impurities. Monosaccharide spectral analysis can not only provide information about the type and number of monosaccharides in the glycan of a protein, but also be used to infer the connection mode and structure of the glycan. Moreover, since different production processes and conditions may cause minor differences in the glycan structure of the drug, monosaccharide spectrum analysis is also an important tool for evaluating drug consistency.

 

MtoZ Biolabs provides drug quality research services that comply with global pharmaceutical regulations. Based on the high-resolution mass spectrometer Obitrap Fusion Lumos, and the Byonic software that includes almost all sugar types, we provide monosaccharide spectrum analysis services for antibody drugs, used to determine the glycosylation sites, N-glycan/O-glycan types, and glycan compositions of recombinant protein samples.