AUC Analysis of Polypeptide Drugs by Ultracentrifugation

Peptide drugs are bioactive molecules formed by connecting multiple amino acids through peptide bonds. Generally, they are formed by connecting 10-100 amino acids, with a relative molecular mass lower than 10000. Most peptide drugs come from endogenous peptides or natural peptides, so they have no or little side effects on the human body. Compared to protein drugs, peptide drugs also have advantages such as good stability, high purity, low production cost, and low immunogenicity. With the rapid development and maturity of peptide synthesis technology, peptide drugs have become the focus of biopharmaceutical research and development in recent years. Currently, peptide drugs are widely used in the diagnosis and treatment of tumors, autoimmune diseases, and certain cardiovascular diseases and diabetes, with broad application prospects.

Analytical Ultracentrifugation (AUC) has a wide range of applications in peptide drug research and development. AUC uses centrifugal force and centrifugal time to analyze the sedimentation behavior of molecules in solution, providing important information about protein structure, interactions, and purity. Specific applications of AUC in peptide drugs include: (1) peptide purity and aggregate analysis; (2) studying the interactions and complex formation of peptide drugs; (3) evaluating peptide stability and aggregate kinetics; (4) quality control in peptide drug development.

MtoZ Biolabs Biotechnology provides drug quality research services that comply with global pharmaceutical regulations for customers. We provide high-resolution, high-sensitivity peptide drug ultracentrifugation AUC technology services. This technology is widely used in the research and development process of peptide drugs, and can provide important information about peptide structure, interaction, purity, stability, and aggregate kinetics. These information are of great significance for the research and development, quality control, and efficacy evaluation of peptide drugs.