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    Central Carbon Metabolism Analysis

      Central carbon metabolism (CCM) governs the core biochemical transformations that provide energy and building blocks for cell growth and survival. It is an intersection of various metabolic pathways, including glycolysis, pentose phosphate pathway, TCA cycle, and anaplerotic reactions. Understanding these interrelated metabolic networks are essential in various fields, including microbial engineering, cancer research, drug discovery, and more.

       

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      Natalya, N. P. et al. Cell Metab. 2016.

      Figure 1. Use of Glycolysis/TCA Cycle Intermediates for Biosynthesis and NADH Production

       

      At MtoZ Biolabs, we offer a comprehensive Central Carbon Metabolism Analysis Service using advanced mass spectrometry-based metabolomics techniques. Our service aims to provide a detailed understanding of the dynamic changes in central carbon metabolic pathways under different conditions, which could potentially uncover novel targets for therapeutic interventions.

       

      Analysis Workflow

      Our analysis workflow includes: Sample Collection, Sample Preparation, LC-MS Analysis, Data Processing and Analysis, Report Generation

       

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      Applications

      Our Central Carbon Metabolism Analysis service is applicable to a wide range of research fields, including but not limited to:

      • Cancer research: Understanding the metabolic reprogramming in cancer cells.
      • Microbial engineering: Optimization of microbial strains for bioproduction.
      • Drug discovery: Identification of potential therapeutic targets in metabolic pathways.
      • Plant and agriculture research: Understanding the metabolic responses of plants under different conditions.

       

      Sample Submission Requirements

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      Deliverables

      1. Experimental Procedures

      2. Relevant Liquid Chromatography and Mass Spectrometry Parameters

      3. Detailed Information on Central Carbon Metabolism Analysis

      4. Raw Data

      5. Custom Analysis Report

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