Ion Chromatography-Based Charge Heterogeneity Analysis Service

In biopharmaceutical processes, particularly for protein and antibody drugs, charge heterogeneity analysis is crucial for ensuring quality control of bioproducts. Interactions between molecules with different charge can significantly impact the bioactivity, immunogenicity, half-life, and charge stability of drugs, ultimately affecting their efficacy, stability, and safety. Ion chromatography (IC) is a widely recognized technique for analyzing charge heterogeneity in biomolecules by leveraging the charge adsorption interaction between charged molecules and ion exchange resins. IC can effectively separate molecules with varying charge states, enabling accurate identification and measurement of charge characteristics in samples. This technology is a key tool for developing and ensuring the quality of vaccines, antibody drugs, enzyme preparations, and other protein-based medications.

 



Figure 1. Charge Heterogeneity Analysis Services by MtoZ Biolabs

 

MtoZ Biolabs has developed an efficient charge heterogeneity analysis platform based on advanced ion exchange chromatography and professional data analysis methods. This platform provides comprehensive services, including routine charge heterogeneity analysis and in-depth charge profiling. Specific services include qualitative and quantitative analysis of charge variants, component analysis of charge heterogeneity, and assessment of how charge state affects drug stability and activity. We offer support across drug development, production, and quality control. Welcome to contact to learn more about our service!

 

Deliverables

1. Experimental Procedures

2. Relevant Mass Spectrometry Parameters

3. Detailed Charge Heterogeneity Analysis by Ion Chromatography

4. Mass Spectrometry Images

5. Raw Data