Chenodeoxycholic Acid Analysis Service
- Rapid Analysis Cycle and Cost-Effectiveness
- Stable, Reliable, and Highly Sensitive Results
- Comprehensive One-Stop Service for Extensive Testing Needs
- User-Friendly Operation with Wide Application Scope
- Supported by Extensive Bioanalytical Resources and Advanced Platforms
Chenodeoxycholic acid (CDCA) is a primary bile acid synthesized in the liver through cholesterol metabolism. CDCA plays a vital role in the bile acid cycle, aiding in the digestion and absorption of fats and regulating cholesterol metabolism. In the intestines, CDCA can also be converted by gut bacteria into secondary bile acids, such as lithocholic acid and deoxycholic acid. Given its critical role in lipid metabolism and cholesterol balance, fluctuations in CDCA levels are closely linked to various conditions, including liver and bile duct diseases, metabolic disorders, and the formation of gallstones. Additionally, abnormal accumulation of CDCA may be associated with pathological processes in certain liver diseases. Therefore, precise analysis of CDCA and its metabolites is essential for clinical research and disease diagnosis.
Figure 1. Molecular Structure of Chenodeoxycholic Acid
MtoZ Biolabs offers Chenodeoxycholic Acid Analysis Service using high performance liquid chromatography-mass spectrometry (HPLC-MS). This advanced method combines the separation capabilities of HPLC with the detection power of MS, ensuring high sensitivity and specificity in CDCA detection.
Analysis Workflow
Service Advantages
Sample Submission Requirements
1. Sample Types
Serum, plasma, urine, feces, tissue extracts, and other biological samples.
2. Sample Volume
At least 200 μL of liquid sample or 200 mg of solid sample.
3. Sample Preservation
Store at -80°C to maintain stability.
Note: Provide details on sample collection and handling.
Applications
1. Liver and Bile Duct Disease Research: Study CDCA level changes to understand its role in conditions such as gallstones and cholestasis.
2. Cholesterol Metabolism Research: Investigate CDCA's involvement in cholesterol metabolism, providing insights for managing hypercholesterolemia.
3. Lipid Metabolism Research: Examine CDCA's function in lipid digestion and absorption to uncover its potential role in metabolic disorders.
4. Drug Development: Explore CDCA's metabolic pathways to support the development of bile acid modulators and related therapies.
5. Toxicity Assessment: Assess the toxic effects of CDCA accumulation, particularly in the context of abnormal bile acid metabolism.
Deliverables
1. Experimental Procedures
2. Relevant Liquid Chromatography and Mass Spectrometry Parameters
3. Detailed Information on Chenodeoxycholic Acid
4. Raw Data
5. Custom Analysis Report
MtoZ Biolabs is dedicated to advancing your research and clinical projects by providing detailed insights into CDCA's extensive physiological roles through top-tier analytical techniques and expert services.
How to order?
