Cholic Acid 7 Sulfate Analysis Service

Cholic acid 7 sulfate (CA-7S) is a sulfated derivative of cholic acid, formed through the conjugation of a sulfate group to the 7th hydroxyl position of cholic acid in the liver and intestine. As an agonist of the Takeda G-protein receptor 5 (TGR5), CA-7S enhances TGR5 expression and stimulates GLP-1 secretion. Research indicates that CA-7S levels in feces increase in male mice fed diets supplemented with cholic acid or ursodeoxycholic acid, whereas female mice do not show such an increase. This differential response underscores CA-7S's role in bile acid metabolism and its potential implications for liver function, bile acid regulation, and gastrointestinal health. Accurate measurement of CA-7S is crucial for elucidating its function in health and disease.

Figure 1. Molecular Structure of Cholic Acid 7 Sulfate

MtoZ Biolabs offers Cholic Acid 7 Sulfate Analysis Service using high performance liquid chromatography-mass spectrometry (HPLC-MS). This advanced method combines the separation capabilities of HPLC with the detection power of MS, ensuring high sensitivity and specificity in CA-7S detection.

Analysis Workflow

Service Advantages

1. High Sensitivity

Detects very low concentrations of CA-7S accurately.

2. High Specificity

Differentiates CA-7S from other compounds using mass spectrometry.

3. Rapid Analysis

Efficient sample preparation and fast detection processes for high-throughput analysis.

4. High Accuracy

Strict quality control ensures accuracy and reproducibility.

5. Versatility

Capable of analyzing CA-7S and its related metabolites.

Sample Submission Requirements

Make sure the sample volume is greater than 0.2 g or 0.2 mL. For detailed sample submission information, please contact our customer service.

Deliverables

1. Experimental Procedures

2. Relevant Liquid Chromatography and Mass Spectrometry Parameters

3. Detailed Information on Cholic Acid 7 Sulfate

4. Raw Data

5. Custom Analysis Report

Our Cholic Acid 7 Sulfate Analysis Service provides high-quality data support, advancing your scientific research and applications. For any inquiries or requirements, please contact us.