D-Homocysteine Analysis Service

D-Homocysteine (D-Hcy) is a sulfur-containing amino acid crucial in methionine and folate metabolism. It acts as an important intermediate in the synthesis of proteins and nucleic acids and is involved in methylation reactions. Elevated levels of D-Hcy are risk factors for cardiovascular diseases, neurodegenerative disorders, osteoporosis, and certain cancers. Quantitative and qualitative analysis of D-Hcy and its derivatives provide insights into their roles in physiological and pathological processes, aiding in disease prevention, diagnosis, and treatment.

 



Figure 1. Molecular Structure of Hcy

 

MtoZ Biolabs utilizes liquid chromatography-tandem mass spectrometry (LC-MS/MS) to conduct detailed quantitative and qualitative analyses of D-Hcy and its metabolites. This advanced method integrates LC's rapid separation capabilities with the high detection sensitivity of MS/MS, facilitating the precise measurement of D-Hcy in complex biological matrices.

 

Analysis Workflow

 

 

 

Service Advantages

1. High Sensitivity and Precision

HPLC-MS/MS provides highly sensitive and accurate measurements, suitable for detecting low concentrations of D-Hcy and differentiating its isomers.

 

2. Rapid and Efficient

Optimized sample preparation and fast analysis ensure quick and efficient processing.

 

3. Wide Applicability

Suitable for various biological samples, including blood, urine, and tissues.

 

4. Accurate and Reliable Data

Ensures high reproducibility and low error rates, supporting both research and clinical applications, providing reliable and specific results.

 

Sample Submission Requirements

Please ensure that the sample volume is greater than 0.2 g or 0.2 mL.

 

Applications

Cardiovascular disease research: Study the role of D-Homocysteine in atherosclerosis and cardiovascular diseases.

 

Neurodegenerative disease research: Examine the relationship between D-Homocysteine levels and Alzheimer's and Parkinson's diseases.

 

Metabolic disease research: Identify the role of D-Homocysteine in diabetes and other metabolic disorders.

 

Nutrition and health assessment: Evaluate D-Homocysteine levels to assess nutritional status and prevent related diseases.

 

Deliverables

1. Experimental Procedures

2. Relevant Liquid Chromatography and Mass Spectrometry Parameters

3. Detailed Information on D-Hcy and their Metabolites

4. Raw Data

5. Custom Analysis Report

 

MtoZ Biolabs is dedicated to advancing your research and clinical projects by providing detailed insights into D-Hcy's extensive physiological roles through top-tier analytical techniques and expert services.